European Journal of Applied Physiology and Occupational Physiology

, Volume 76, Issue 2, pp 192–194

Moderate exercise leads to decreased expression of β1 and β2 integrins on leucocytes

Authors

  • Jens Jordan
    • Franz Volhard Clinic at the Max Delbrück Center of Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Germany
  • Ralph Beneke
    • Department of Sports Medicine, Free University of Berlin, Germany
  • Mathias Hütler
    • Department of Sports Medicine, Free University of Berlin, Germany
  • Alexander Veith
    • Franz Volhard Clinic at the Max Delbrück Center of Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Germany
  • Hermann Haller
    • Franz Volhard Clinic at the Max Delbrück Center of Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Germany
  • Friedrich C. Luft
    • Franz Volhard Clinic at the Max Delbrück Center of Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Germany
SHORT COMMUNICATION

DOI: 10.1007/s004210050234

Cite this article as:
Jordan, J., Beneke, R., Hütler, M. et al. Eur J Appl Physiol (1997) 76: 192. doi:10.1007/s004210050234

Abstract

 Intravascular adhesion of leucocytes plays a role in the pathogenesis of acute and chronic vascular disease. Regular aerobic exercise seems to protect against vascular disease. Since leucocyte adhesion is mediated by integrins, we tested the hypothesis that surface expression of the integrin adhesive receptors LFA-1 (cd11a/cd18), MAC-1 (cd11b/cd18), gp 150/95 (cd11c/cd18), and VLA-4 (cd29/cd49) is decreased by moderate endurance exercise. Surface expression of integrins was measured by FACS analysis in 19 healthy subjects (16 males, 3 females, 36.6 ± 8.7 years, 177.1 ± 7.5 cm, 70.3 ± 8.1 kg) before and after submaximal exercise (3 h run) using monoclonal antibodies against cd11a, cd11b, cd11c, cd18, cd29 and cd49. In addition, we compared resting integrin expression in this group with a group of sedentary subjects (19 males, 6 females, 29.3 ± 5.3 years). White blood cell count increased from 5300 ml–1 to 9740 ml–1 during exercise (P<0.001). Nevertheless, the expression (indicated by the mean log fluorescence) of cd11a (94 ± 24 vs. 78 ± 14) and cd18 (128 ± 31 vs. 102 ± 21) on lymphocytes and of cd11a (104 ± 25 vs. 85 ± 16), cd11c (497 ± 171 vs. 408 ± 126) cd29 (109 ± 16 vs. 89 ± 16), cd49 (69± 8 vs. 54 ± 11) on monocytes was decreased after exercise (all P<0.05). In contrast, integrin expression on granulocytes was not altered by exercise. Comparison of exercising and sedentary subjects showed a significantly decreased expression of integrins in exercising subjects. Our results demonstrate that moderate exercise leads to decreased expression of integrin receptors on leucocytes. This decreased expression of adhesion molecules may result in decreased adhesion and infiltration of leucocytes into the vessel wall. This phenomenon may play a role in the beneficial effect of moderate exercise in prevention of acute and chronic vascular disease.

Key words Leucocytes Integrins Endurance exercise

Copyright information

© Springer-Verlag Berlin Heidelberg 1997