ORIGINAL ARTICLE

European Journal of Applied Physiology and Occupational Physiology

, Volume 76, Issue 1, pp 32-40

First online:

Resistance exercise training and the orthostatic response

  • John P. McCarthyAffiliated withNASA Johnson Space Center, Medical Life Sciences Division (SD/3) Houston, TX 77058, USA
  • , Marcas M. BammanAffiliated withKRUG Life Sciences Inc., 1290 Hercules, Suite 120, Houston, TX 77058, USA
  • , Janice M. YelleAffiliated withNASA Johnson Space Center, Medical Life Sciences Division (SD/3) Houston, TX 77058, USA
  • , Adrian D. LeBlancAffiliated withBaylor College of Medicine, 6550 Fannin St., Houston, TX 77030, USA
  • , Roger M. RoweAffiliated withBaylor College of Medicine, 6550 Fannin St., Houston, TX 77030, USA
  • , Michael C. GreenisenAffiliated withNASA Johnson Space Center, Medical Life Sciences Division (SD/3) Houston, TX 77058, USA
  • , Stuart M. C. LeeAffiliated withKRUG Life Sciences Inc., 1290 Hercules, Suite 120, Houston, TX 77058, USA
  • , Elisabeth R. SpectorAffiliated withKRUG Life Sciences Inc., 1290 Hercules, Suite 120, Houston, TX 77058, USA
  • , Suzanne M. FortneyAffiliated withNASA Johnson Space Center, Medical Life Sciences Division (SD/3) Houston, TX 77058, USA

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Abstract

Resistance exercise has been suggested to increase blood volume, increase the sensitivity of the carotid baroreceptor cardiac reflex response (BARO), and decrease leg compliance, all factors that are expected to improve orthostatic tolerance. To further test these hypotheses, cardiovascular responses to standing and to pre-syncopal limited lower body negative pressure (LBNP) were measured in two groups of sedentary men before and after a 12-week period of either exercise (n = 10) or no exercise (control, n = 9). Resistance exercise training consisted of nine isotonic exercises, four sets of each, 3 days per week, stressing all major muscle groups. After exercise training, leg muscle volumes increased (P < 0.05) by 4–14%, lean body mass increased (P = 0.00) by 2.0 (0.5) kg, leg compliance and BARO were not significantly altered, and the maximal LBNP tolerated without pre-syncope was not significantly different. Supine resting heart rate was reduced (P = 0.03) without attenuating the heart rate or blood pressure responses during the stand test or LBNP. Also, blood volume (125I and 51Cr) and red cell mass were increased (P < 0.02) by 2.8% and 3.9%, respectively. These findings indicate that intense resistance exercise increases blood volume but does not consistently improve orthostatic tolerance.

Key words Blood volume Carotid baroreflexes Leg compliance Blood pressure Muscle mass