European Journal of Applied Physiology

, Volume 113, Issue 2, pp 349–357

The effect of acute exercise in hypoxia on flow-mediated vasodilation

  • Keisho Katayama
  • Osamu Fujita
  • Motoyuki Iemitsu
  • Hiroshi Kawano
  • Erika Iwamoto
  • Mitsuru Saito
  • Koji Ishida
Original Article

DOI: 10.1007/s00421-012-2442-5

Cite this article as:
Katayama, K., Fujita, O., Iemitsu, M. et al. Eur J Appl Physiol (2013) 113: 349. doi:10.1007/s00421-012-2442-5

Abstract

The purpose of this study was to clarify the effect of acute exercise in hypoxia on flow-mediated vasodilation (FMD). Eight males participated in this study. Two maximal exercise tests were performed using arm cycle ergometry to estimate peak oxygen uptake \( \left( {\dot{V}{\text{O}}_{{ 2 {\text{peak}}}} } \right) \) while breathing normoxic [inspired O2 fraction (FIO2) = 0.21] or hypoxic (FIO2 = 0.12) gas mixtures. Next, subjects performed submaximal exercise at the same relative exercise intensity \( \left( {30\,\% \;\dot{V}{\text{O}}_{{ 2 {\text{peak}}}} } \right) \) in normoxia or hypoxia for 30 min. Before (Pre) and after exercise (Post 5, 30, and 60 min), brachial artery FMD was measured during reactive hyperemia by ultrasound under normoxic conditions. FMD was estimated as the percent (%) rise in the peak diameter from the baseline value at prior occlusion at each FMD measurement (%FMD). The area under the curve for the shear rate stimulus (SRAUC) was calculated in each measurement, and each %FMD value was normalized to SRAUC (normalized FMD). %FMD and normalized FMD decreased significantly (P < 0.05) immediately after exercise in both condition (mean ± SE, FMD, normoxic trial, Pre: 8.85 ± 0.58 %, Post 5: −0.01 ± 1.30 %, hypoxic trial, Pre: 8.84 ± 0.63 %, Post 5: 2.56 ± 0.83 %). At Post 30 and 60, %FMD and normalized FMD returned gradually to pre-exercise levels in both trials (FMD, normoxic trial, Post 30: 1.51 ± 0.68 %, Post 60: 2.99 ± 0.79 %; hypoxic trial, Post 30: 4.57 ± 0.78 %, Post 60: 6.15 ± 1.20 %). %FMD and normalized FMD following hypoxic exercise (at Post 5, 30, and 60) were significantly (P < 0.05) higher than after normoxic exercise. These results suggest that aerobic exercise in hypoxia has a significant impact on endothelial-mediated vasodilation.

Keywords

Aerobic exercise Vasodilation Flow-mediated dilation Hypoxia 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Keisho Katayama
    • 1
  • Osamu Fujita
    • 2
  • Motoyuki Iemitsu
    • 3
  • Hiroshi Kawano
    • 4
  • Erika Iwamoto
    • 5
  • Mitsuru Saito
    • 6
  • Koji Ishida
    • 1
  1. 1.Research Center of Health, Physical Fitness and Sports, Nagoya UniversityNagoyaJapan
  2. 2.Graduate School of Education and Human DevelopmentNagoya UniversityNagoyaJapan
  3. 3.Faculty of Sport and Health ScienceRitsumeikan UniversityKusatsuJapan
  4. 4.Faculty of Sport SciencesWaseda UniversityTokyoJapan
  5. 5.Graduate School of MedicineNagoya UniversityNagoyaJapan
  6. 6.Faculty of Psychological and Physical ScienceAichigakuin UniversityNisshinJapan

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