European Journal of Applied Physiology

, Volume 111, Issue 5, pp 749–756

Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial

  • Bruno Gualano
  • Vitor de Salles Painelli
  • Hamilton Roschel
  • Rebeca Lugaresi
  • Egidio Dorea
  • Guilherme Giannini Artioli
  • Fernanda Rodrigues Lima
  • Maria Elizabeth Rossi da Silva
  • Maria Rosária Cunha
  • Antonio Carlos Seguro
  • Maria Heloisa Shimizu
  • Maria Concepción García Otaduy
  • Marcelo Tatit Sapienza
  • Cláudia da Costa Leite
  • Eloisa Bonfá
  • Antonio Herbert Lancha Junior
Original Article

DOI: 10.1007/s00421-010-1676-3

Cite this article as:
Gualano, B., de Salles Painelli, V., Roschel, H. et al. Eur J Appl Physiol (2011) 111: 749. doi:10.1007/s00421-010-1676-3

Abstract

Creatine supplementation may have a therapeutic role in diabetes, but it is uncertain whether this supplement is safe for kidney function. The aim of this study was to investigate the effects of creatine supplementation on kidney function in type 2 diabetic patients. A randomized, double-blind, placebo-controlled trial was performed. The patients were randomly allocated to receive either creatine or placebo for 12 weeks. All the patients underwent exercise training throughout the trial. Subjects were assessed at baseline and after the intervention. Blood samples and 24-h urine samples were obtained for kidney function assessments. Additionally, 51Cr-EDTA clearance was performed. To ensure the compliance with creatine intake, we also assessed muscle phosphorylcreatine content. The creatine group presented higher muscle phosphorylcreatine content when compared to placebo group (CR Pre 44 ± 10, Post 70 ± 18 mmol/kg/wt; PL Pre 52 ± 13, Post 46 ± 13 mmol/kg/wt; p = 0.03; estimated difference between means 23.6; 95% confidence interval 1.42–45.8). No significant differences were observed for 51Cr-EDTA clearance (CR Pre 90.4 ± 16.9, Post 96.1 ± 15.0 mL/min/1.73 m2; PL Pre 97.9 ± 21.6, Post 96.4 ± 26.8 mL/min/1.73 m2; p = 0.58; estimated difference between means −0.3; 95% confidence interval −24.9 to 24.2). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria were unchanged. CR supplementation does not affect kidney function in type 2 diabetic patients, opening a window of opportunities to explore its promising therapeutic role in this population. ClinicalTrials.gov registration number: NCT00992043.

Keywords

PhosphorylcreatineChronic kidney diseaseDiabetesGlomerular filtration rate

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Bruno Gualano
    • 1
    • 2
    • 8
  • Vitor de Salles Painelli
    • 1
    • 2
  • Hamilton Roschel
    • 1
    • 2
  • Rebeca Lugaresi
    • 1
  • Egidio Dorea
    • 3
  • Guilherme Giannini Artioli
    • 1
    • 2
  • Fernanda Rodrigues Lima
    • 2
  • Maria Elizabeth Rossi da Silva
    • 4
  • Maria Rosária Cunha
    • 4
  • Antonio Carlos Seguro
    • 5
  • Maria Heloisa Shimizu
    • 5
  • Maria Concepción García Otaduy
    • 6
  • Marcelo Tatit Sapienza
    • 7
  • Cláudia da Costa Leite
    • 6
  • Eloisa Bonfá
    • 2
  • Antonio Herbert Lancha Junior
    • 1
  1. 1.Laboratory of Applied Nutrition and MetabolismSchool of Physical Education and Sports, University of Sao PauloSao PauloBrazil
  2. 2.Division of RheumatologySchool of Medicine, University of Sao PauloSao PauloBrazil
  3. 3.University of Sao Paulo, University HospitalSao PauloBrazil
  4. 4.Laboratory of Medical Investigation, LIM18, Division of EndocrinologySchool of Medicine, University of Sao PauloSao PauloBrazil
  5. 5.Division of NephrologySchool of Medicine, University of Sao PauloSao PauloBrazil
  6. 6.Division of Radiology, LIM44School of Medicine, University of Sao PauloSao PauloBrazil
  7. 7.Division of Nuclear MedicineSchool of Medicine, University of Sao PauloSao PauloBrazil
  8. 8.Sao PauloBrazil