European Journal of Applied Physiology

, Volume 111, Issue 2, pp 203–210

Short-term unilateral leg immobilization alters peripheral but not central arterial structure and function in healthy young humans


    • Department of KinesiologyMcMaster University
    • Faculty of Biological SciencesUniversity of Leeds
  • Jennifer Crozier
    • Department of KinesiologyMcMaster University
  • Elisa I. Glover
    • Department of KinesiologyMcMaster University
  • Nobuo Yasuda
    • Department of KinesiologyMcMaster University
  • Stuart M. Phillips
    • Department of KinesiologyMcMaster University
  • Mark A. Tarnopolsky
    • Department of Pediatrics and NeurologyMcMaster University
  • Maureen J. MacDonald
    • Department of KinesiologyMcMaster University
Original Article

DOI: 10.1007/s00421-010-1636-y

Cite this article as:
Rakobowchuk, M., Crozier, J., Glover, E.I. et al. Eur J Appl Physiol (2011) 111: 203. doi:10.1007/s00421-010-1636-y


Short-term leg immobilization is an acute model of inactivity, which induces vascular deconditioning. The present study was conducted to determine if short-term leg immobilization induced alterations in central and peripheral conduit artery structure (diameter and compliance), function (resting blood flow and mean wall shear rate), and peripheral flow-mediated dilation. Healthy participants (n = 7 women and n = 8 men) were studied before and after 12 days of unilateral leg immobilization. Carotid artery structure and function were unaltered with immobilization indicating that the unilateral immobilization did not have a detectable effect on this representative central artery. In contrast, peripheral measures of arterial structure at the common femoral and popliteal arteries showed significant reductions in both the immobilized and non-immobilized limbs but to a greater extent in the immobilized limbs. Specifically, femoral and popliteal artery compliance and femoral artery diameter were reduced in both the immobilized and the non-immobilized limb (p < 0.05) while popliteal artery diameter was reduced only in the immobilized leg. Popliteal artery flow-mediated dilation, an indicator of peripheral artery function, was increased in the immobilized limb, which parallels reports in paralyzed limbs of spinal-cord-injured individuals. The time course of vascular alterations with inactivity likely follows a sequence of adaptations in arterial structure and function reflecting differing initial flow patterns, and arterial wall composition, and diverse hemodynamic stimuli within different blood vessels.


Blood flowEndothelial functionDeconditioning

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© Springer-Verlag 2010