European Journal of Applied Physiology

, 103:561

Interleukin-1 receptor antagonist restores homeostatic function and limits multiorgan damage in heatstroke

  • Kun-Hung Shen
  • Chen-Kuei Chang
  • Mao-Tsun Lin
  • Ching-Ping Chang
Original Article

DOI: 10.1007/s00421-008-0755-1

Cite this article as:
Shen, K., Chang, C., Lin, M. et al. Eur J Appl Physiol (2008) 103: 561. doi:10.1007/s00421-008-0755-1

Abstract

We attempt to investigate whether interleukin-1 receptor antagonist (IL-1ra) therapy improves survival during heatstroke by attenuating multiorgan dysfunction. Anesthetized rabbits, immediately after the onset of heatstroke, are divided into three major groups and given: nothing, normal saline (1 ml/kg, i.v.), or IL-1ra (200–400 μg per 1 ml/kg, i.v.). They are exposed to ambient temperature of 40°C to induce heatstroke. Another group of rabbits is exposed to room temperature (24°C) and used as normothermic controls. Hyperthermia, hypotension, cerebral ischemia and edema, hepatic and renal failure, increased levels of both nitric oxide metabolites (NOx) and dihydroxybenzoic acid (DHBA) in plasma, hyperkalemia, respiratory alkalosis, and metabolic acidosis and hypoxia are all observed in vehicle-treated heatstroke animals. When the vehicle-treated animals undergo heat stress, their survival time values are found to be 12–18 min. Resuscitation with IL-1ra dose-dependently improves survival time (duration, 132–303 min). As compared with vehicle-treated heatstroke rabbits, IL-1ra therapy significantly causes attenuation of heatstroke-induced hyperthermia, hypotension, cerebral ischemia and edema, intracranial hypertension, hepatic and renal dysfunction, NOx and DHBA overproduction, hyperkalemia, hypoxia, respiratory alkalosis, and metabolic acidosis. The results indicate that IL-1ra therapy may restore tissue blood flow and homeostatic function, and limit multiorgan dysfunction and death in heatstroke.

Keywords

HeatstrokeInterleukin-1 receptor antagonistMultiorgan dysfunctionHyperkalemiaAcidosis

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Kun-Hung Shen
    • 3
    • 4
  • Chen-Kuei Chang
    • 5
    • 6
  • Mao-Tsun Lin
    • 1
    • 2
  • Ching-Ping Chang
    • 1
    • 2
  1. 1.Department of BiotechnologySouthern Taiwan University of TechnologyTainanTaiwan
  2. 2.Department of Medical ResearchChi Mei Medical CenterTainanTaiwan
  3. 3.Department of UrologyTaipei Medical UniversityTaipeiTaiwan
  4. 4.Department of UrologyChi Mei Medical CenterTainanTaiwan
  5. 5.Department of SurgeryMackay Memorial HospitalTaipeiTaiwan
  6. 6.Graduate Institute of Injury Prevention and ControlTaipei Medical University and Wan-Fan HospitalTaipeiTaiwan