International Archives of Occupational and Environmental Health

, Volume 86, Issue 8, pp 943–955

Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium

Authors

    • Institute and Policlinic of Occupational and Social Medicine (IPAS)Technical University Dresden
  • Sabine Jähnichen
    • Institute and Policlinic of Occupational and Social Medicine (IPAS)Technical University Dresden
  • Janice Hegewald
    • Institute and Policlinic of Occupational and Social Medicine (IPAS)Technical University Dresden
  • Alba Fishta
    • Institute and Policlinic of Occupational and Social Medicine (IPAS)Technical University Dresden
  • Olga Krug
    • Department of Occupational, Social and Environmental MedicineUniversity Medical Center Göttingen
  • Luisa Rüter
    • Department of Occupational, Social and Environmental MedicineUniversity Medical Center Göttingen
  • Claudia Strik
    • Department of Occupational, Social and Environmental MedicineUniversity Medical Center Göttingen
  • Ernst Hallier
    • Department of Occupational, Social and Environmental MedicineUniversity Medical Center Göttingen
  • Sebastian Straube
    • Department of Occupational, Social and Environmental MedicineUniversity Medical Center Göttingen
Original Article

DOI: 10.1007/s00420-012-0822-0

Cite this article as:
Seidler, A., Jähnichen, S., Hegewald, J. et al. Int Arch Occup Environ Health (2013) 86: 943. doi:10.1007/s00420-012-0822-0

Abstract

Aim

To investigate the exposure-risk relationship for occupational chromium (VI) exposure and lung cancer in order to establish exposure limits.

Methods

We systematically searched for studies reporting on occupational Cr(VI) exposure and cancers of the respiratory tract. To be included, studies needed to provide data for more than one level of occupational Cr(VI) exposure, adequately consider the confounder smoking and be of adequate methodological quality. Because direct genotoxicity was considered the predominant mechanism of carcinogenesis of Cr(VI), linear models were applied in order to fit risk data. Relative risks were calculated based on these linear regression models and then used to estimate excess absolute risks.

Results

Five studies of two cohorts of chromium production workers in Baltimore, Maryland, and Painesville, Ohio, were included. Based on different estimates for the exposure effect, the absolute excess risk was found to be “acceptable” (less than 4 per 10,000 according to the German Committee on Hazardous Substances, “AGS”) at a Cr(VI) concentration of 0.1 μg/m3, and became “intolerable” (more than 4 per 1,000) beyond a Cr(VI) concentration of 1 μg/m3.

Conclusion

Occupational exposure limits for Cr(VI) based on excess absolute risks can be derived from published data identified by a systematic literature review.

Keywords

ChromiumOccupational exposureSystematic reviewExposure-risk relationship

Copyright information

© Springer-Verlag Berlin Heidelberg 2012