International Archives of Occupational and Environmental Health

, Volume 86, Issue 3, pp 321–332

Distributed lag associations between respiratory illnesses and mortality with suspended particle concentration in Tula, a highly polluted industrial region in Central Mexico

Authors

  • Eva M. Melgar-Paniagua
    • Departamento de ToxicologíaCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
  • Elizabeth Vega-Rangel
    • Programas de InvestigaciónInstituto Mexicano del Petróleo
  • Luz M. Del Razo
    • Departamento de ToxicologíaCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
  • Carlos A. Lucho-Constantino
    • Ingeniería en BiotecnologíaUniversidad Politécnica de Pachuca
  • Stephen J. Rothenberg
    • Departamento de ToxicologíaCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
    • Centro de Investigaciones en Salud PoblacionalInstituto Nacional de Salud Pública, Universidad No. 655, Col. Santa María Ahuacatitlán
    • Departamento de ToxicologíaCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
Original Article

DOI: 10.1007/s00420-012-0768-2

Cite this article as:
Melgar-Paniagua, E.M., Vega-Rangel, E., Del Razo, L.M. et al. Int Arch Occup Environ Health (2013) 86: 321. doi:10.1007/s00420-012-0768-2

Abstract

Purpose

We aimed to evaluate the association between changes in airborne particulate matter concentration (PM) with changes in cases of mortality, acute respiratory infections (ARI) and asthma over 2004–2008 in an industrialized and polluted region in central Mexico.

Methods

A generalized linear model with a Poisson distribution and a negative binomial analysis was used to evaluate the influence of PM and temperature on all-cause mortality (All-cause-M), cause-specific mortality (Cause-specific-M), ARI and asthma, using cubic spline functions and distributed lags of PM. Estimated changes in relative risk were calculated for an exposure corresponding to each increase of 10 μg/m3 in PM level.

Results

Associations between PM and mortality and morbidity were statistically most consistent for total suspended particulate (TSP) than for particulate matter <10 μM aerodynamic diameter (PM10). The greatest effects in mortality were observed with a 3-week lag, and effects were greater for Cause-specific-M. We also found a displacement effect up to 4-week lag for Cause-specific-M and TSP. The greatest effects in morbidity were observed at 0-week lag, yet they were statistically marginal and were greater for asthma. We found a displacement effect at 4–5–6-week lag for asthma and TSP. All associations of mortality and morbidity, expressed as change in relative risk, were greater with PM10; however, all of them were statistically marginal.

Conclusions

Increased respiratory morbidity and mortality is associated with weekly changes of PM air pollution in the region. A reduction in air pollutants from industrial sources would benefit life quality and health of the exposed population.

Keywords

Respiratory illnessesMortalityAir pollutionGeneralized linear modelDistributed lag modelTime-series

Copyright information

© Springer-Verlag 2012