Response to the letter to the editor entitled “Regarding long-term lead elimination from plasma and whole blood after poisoning”
In relation to our paper on plasma lead in poisoned subjects (Rentschler et al. 2011), professor Sanaei-Zadeh asks for additional information on three aspects: (1) laboratory status regarding kidneys, liver, and bone marrow (2) our definition of “severe poisoning”, and (3) treatment.
All five cases had serum creatinine concentrations within the reference limits of our laboratory. Determination of blood urea nitrogen is not a clinical routine in our department. As regards serum transferases, case No. 3 had a slight, transient rise initially [aspartate aminotransferase: 0.88 (upper reference limit 0.60) μkat/L; alanine aminotransferase: 1.1 (0.75) μkat/L)], while all the others were “normal”. Cases No. 1, 3, and 5 had typical microcytic sideroblastic anemia in bone marrow biopsies. Only case No. 5 was examined for basophilic stippling of erythrocytes in peripheral blood; he displayed such.
We agree that our use of “severe” in some of the present cases may not be full ...
- Rentschler G, Broberg K, Lundh T, Skerfving S (2011) Long-term lead elimination from plasma and whole blood after poisoning. Int Arch Occup Environ Health. doi:10.1007/s00420-011-0673-0
- Skerfving, S, Bergdahl, IA Lead. In: Nordberg, GF, Fowler, BA, Nordberg, M, Friberg, LT eds. (2007) Handbook on the toxicology of metals. Academic Press, New York, pp. 599-643 CrossRef
- Response to the letter to the editor entitled “Regarding long-term lead elimination from plasma and whole blood after poisoning”
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International Archives of Occupational and Environmental Health
Volume 85, Issue 3 , p 339
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