, Volume 85, Issue 3, p 339,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 01 Sep 2011

Response to the letter to the editor entitled “Regarding long-term lead elimination from plasma and whole blood after poisoning”

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Dear Sir,

In relation to our paper on plasma lead in poisoned subjects (Rentschler et al. 2011), professor Sanaei-Zadeh asks for additional information on three aspects: (1) laboratory status regarding kidneys, liver, and bone marrow (2) our definition of “severe poisoning”, and (3) treatment.

Ad (1):

All five cases had serum creatinine concentrations within the reference limits of our laboratory. Determination of blood urea nitrogen is not a clinical routine in our department. As regards serum transferases, case No. 3 had a slight, transient rise initially [aspartate aminotransferase: 0.88 (upper reference limit 0.60) μkat/L; alanine aminotransferase: 1.1 (0.75) μkat/L)], while all the others were “normal”. Cases No. 1, 3, and 5 had typical microcytic sideroblastic anemia in bone marrow biopsies. Only case No. 5 was examined for basophilic stippling of erythrocytes in peripheral blood; he displayed such.

Ad (2):

We agree that our use of “severe” in some of the present cases may not be full ...