, Volume 85, Issue 3, pp 311-316,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 24 Jun 2011

Long-term lead elimination from plasma and whole blood after poisoning

Abstract

Objective

Blood lead (B–Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P–Pb) is more adequate.

Methods

A long-term follow-up study of five cases of lead poisoning. P–Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

Results

P–Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P–Pb was about 1 month; B–Pb decay was much slower.

Conclusion

P–Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.