Renal impairment caused by chronic occupational chromate exposure
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To determine the nephritic toxicity of chromate after chronic occupational exposure.
The environmental contamination was assessed by measuring the chromium (Cr) in 8-h airborne sampler. The integrated level of Cr was determined by Cr concentrations in the whole blood (WB-Cr) and the urine (U-Cr). The renal glomerular and tubule impairment was evaluated by determination of cystatin C (Cys-C) in the serum and microalbumin (mALB), urinary beta2-microglobulin (β2M), N-acetyl-beta-d-glucosaminidase (NAG) activity in the urine.
The mean occupational exposure time to Cr was 12.86 years with average daily air level of 27.13 μg/m3 comparing to 0.11 μg/m3 of the background level. The WB-Cr and U-Cr were 23.49 μg/L and 17.41 μg/g creatinine (Cre), respectively in the chromate-exposed workers comparing to 3.32 μg/L and 1.52 μg/g Cre in the controls. The serum Cys-C and urinary mALB were significantly increased in the chromate-exposed workers. Exposure to Cr seems to induce an enhanced level of urinary NAG activity and β2M concentration. The increased serum Cys-C concentration was positively correlated with the level of serum Cre. The U-Cr was positively correlated to the concentrations of urinary mALB, β2M, and the activity of NAG.
Chronic occupational exposure to chromate causes comprehensive renal impairment though more severity could occur in the tubule than in the glomeruler.
- Renal impairment caused by chronic occupational chromate exposure
International Archives of Occupational and Environmental Health
Volume 84, Issue 4 , pp 393-401
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Occupational exposure
- Renal impairment
- Urinary enzyme
- Urinary proteins
- Industry Sectors
- Author Affiliations
- 1. Department of Laboratory Medicine, The Third Hospital of Peking University, Beijing, China
- 2. Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Peking University, Xueyuan Road, 100191, Haidian District, Beijing, China
- 3. Center for Disease Control and Prevention, Jinan City, Shandong Province, China
- 4. Laboratory for Bio-Environmental Health Sciences, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China