International Archives of Occupational and Environmental Health

, 82:771

Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction

  • Kerstin Kronholm Diab
  • Lennart Truedsson
  • Maria Albin
  • Jørn Nielsen
Original Article

DOI: 10.1007/s00420-008-0392-3

Cite this article as:
Diab, K.K., Truedsson, L., Albin, M. et al. Int Arch Occup Environ Health (2009) 82: 771. doi:10.1007/s00420-008-0392-3
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Abstract

Purpose

The aim of this study was to examine the effects of persulphate on the nasal mucosa and on the immune cells in hairdressers suffering from bleaching powder associated rhinitis (BAR) versus subjects with rhinitis not previously exposed to bleaching powder.

Methods

Fifteen hairdressers (S) with BAR, 14 without symptoms (WS) and 12 atopics (A) with rhinitis but without exposure to bleaching powder were studied. Each performed a nasal challenge with persulphates. Effect parameters were symptom score, acoustic rhinometry, albumin in nasal lavage, subpopulations of lymphocytes in blood and specific serum antibodies.

Results

The S group had a post-challenge increase in nasal symptoms and nasal lavage albumin. The A group reacted to a lesser intent. The S and A groups showed an increase in Th1 cells. An HLA class II cell expression was noticed in both groups of hairdressers. No evidence of a type 1 reaction (immediate type) to persulphate was noticed.

Conclusions

Persulphate challenge affects hairdressers with BAR, but also atopics. The reaction may be driven by a Th1 cell activation.

Keywords

Bleaching powderHairdressersIgENasal challengePersulphateRhinitis

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Kerstin Kronholm Diab
    • 1
  • Lennart Truedsson
    • 2
  • Maria Albin
    • 1
  • Jørn Nielsen
    • 1
  1. 1.Department of Occupational and Environmental MedicineUniversity HospitalLundSweden
  2. 2.Department of Clinical Microbiology and ImmunologyUniversity HospitalLundSweden