Abstract
Studies on the influence of aging on the longitudinal mechanical response of elastic arteries are rare, though longitudinal behavior may have a significant effect on pressure pulse transmission. Our study was designed to elucidate how aging is reflected in changes of the longitudinal prestress, prestretch, and pretension force. The study involved ten human samples (six female and four male) of the abdominal aorta with longitudinal prestretch determined in autopsy. Cylindrical samples underwent a longitudinal elongation test in order to estimate the force necessary to attain the in situ length and to determine the corresponding axial prestress. The elastic modulus was estimated employing hyperelastic limiting chain extensibility model. It was found that pretension force, longitudinal prestress, and prestretch are negatively correlated with age. The decreased longitudinal force necessary to obtain the in situ length suggested that the decrease in the prestress occurs not only due to the age-related increase in the cross-section area. Since elastin is the main constituent responsible for bearing the prestretch, this suggests that the observed decrease in the longitudinal prestress and prestretch reflects aging-induced damage to the elastin. Finally, constitutive modeling showed that limiting chain extensibility is a concept that is suitable for describing the aging effect.
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Horny L., Adamek T., Gultova E., Zitny R., Vesely J., Chlup H., Konvickova S.: Correlations between age, prestrain, diameter and atherosclerosis in the male abdominal aorta. J. Mech. Behav. Biomed. Mater. 4, 2128–2132 (2011). doi:10.1016/j.jmbbm.2011.07.011
Learoyd B.M., Taylor M.G.: Alterations with age in the viscoelastic properties of human arterial walls. Circ. Res. 18, 278–292 (1966)
Dobrin P.B., Doyle J.M.: Vascular smooth muscle and the anisotropy of dog carotid artery. Circ. Res. 27, 105–119 (1970)
Schulze-Bauer C.A.J., Morth C., Holzapfel G.A.: Passive biaxial mechanical response of aged human iliac arteries. J. Biomech. Eng. 125, 395–406 (2003). doi:10.1115/1.1574331
Sommer G., Regitnig P., Költringer L., Holzapfel G.A.: Biaxial mechanical properties of intact and layer-disected human carotid arteries at physiological and supraphysiological loadings. Am. J. Physiol. Heart Circ. Physiol. 298, 898–912 (2010). doi:10.1152/ajpheart.00378.2009
Han H.C., Ku D.N., Vito R.P.: Arterial wall adaptation under elevated longitudinal stretch in organ culture. Ann. Biomed. Eng. 31, 403–411 (2003). doi:10.1114/1.1561291
Humphrey J.D., Eberth J.F., Dye W.W., Gleason R.L.: Fundamental role of axial stress in compensatory adaptations by arteries. J. Biomech. 42, 1–8 (2009). doi:10.1016/j.jbiomech.2008.11.011
Jackson Z.S., Gotlieb A.I., Langille B.L.: Wall tissue remodeling regulates longitudinal tension in arteries. Circ. Res. 90, 918–925 (2002). doi:10.1161/01.RES.0000016481.87703.CC
Jackson Z.S., Dajnowiec D., Gotlieb A.I., Langille B.L.: Partial off-loading of longitudinal tension induces arterial tortuosity. Arterioscler Thromb. Vasc. Biol. 25, 957–962 (2005). doi:10.1161/01.ATV.0000161277.46464.11
Lee Y.-U., Drury-Stewart D., Vito R.P., Han H.-C.: Morphologic adaptation of arterial endothelial cells to longitudinal stretch in organ culture. J. Biomech. 41, 3274–3277 (2008). doi:10.1016/j.jbiomech.2008.08.016
Davis N.P., Han H.C., Wayman B., Vito R.: Sustained axial loading lengthens arteries in organ culture. Ann. Biomed. Eng. 33, 867–877 (2005). doi:10.1007/s10439-005-3488-x
Dobrin P.B., Schwarcz T.H., Mirkvicka R.: Longitudinal retractive force in pressurized dog and human arteries. J. Surg. Res. 48, 116–120 (1990). doi:10.1016/0022-4804(90)90202-D
Lee A.Y., Han B., Lamm S.D., Fierro C.A., Han H.-C.: Effects of elastin degradation and surrounding matrix support on artery stability. Am. J. Physiol. Heart Circ. Physiol. 302, 873–884 (2012). doi:10.1152/ajpheart.00463.2011
Carta L., Wagenseil J.E., Knutsen R.H., Mariko B., Faury G., Davis E.C. et al.: Discrete contributions of elastic fiber components to arterial development and mechanical compliance. Arterioscler Thromb. Vasc. Biol. 29, 2083–2089 (2009). doi:10.1161/ATVBAHA.109.193227
Wagenseil J.E., Mecham R.P.: Elastin in large artery stiffness and hypertension. J. Cardiovasc. Trans. Res. 5, 264–273 (2012). doi:10.1007/s12265-012-9349-8
Langewouters G.J., Wesseling K.H., Goedhard W.J.A.: The static elastic properties of 45 human thoracic and 20 abdominal aortas in vitro and the parameters of a new model. J. Biomech. 17, 425–435 (1984)
Han H.C., Fung Y.C.: Longitudinal strain of canine and porcine aortas. J. Biomech. 28, 637–641 (1995). doi:10.1016/0021-9290(94)00091-H
Horny L., Adamek T., Chlup H., Zitny R.: Age estimation based on a combined arteriosclerotic index. Int. J. Leg. Med. 126, 321–326 (2012). doi:10.1007/s00414-011-0653-7
Horny L., Adamek T., Vesely J., Chlup H., Zitny R., Konvickova S.: Age-related distribution of longitudinal pre-strain in abdominal aorta with emphasis on forensic application. Forensic. Sci. Int. 214, 18–22 (2012). doi:10.1016/j.forsciint.2011.07.007
Gent A.N.: A new constitutive relation for rubber. Rubber Chem. Technol. 69, 59–61 (1996)
Ogden R.W., Saccomandi G.: Introducing mesoscopic information into constitutive equations for arterial walls. Biomech. Model Mechanobiol. 6, 333–344 (2007). doi:10.1007/s10237-006-0064-8
Holzapfel G.A., Gasser T.C., Ogden R.W.: A new constitutive framework for arterial wall mechanics and a comparative study of material models. J. Elast. 61, 1–48 (2000). doi:10.1023/A:1010835316564
Watton P.N., Ventikos Y., Holzapfel G.A.: Modelling the mechanical response of elastin for arterial tissue. J. Biomech. 42, 1320–1325 (2009). doi:10.1016/j.biomech.2009.03.012
Svensjö S., Björck M., Gürtelschmid M., Gidlund K.D., Hellberg A., Wanhainen A.: Low prevalence of abdominal aortic aneurysm among 65-year-old swedish men indicates a change in the epidemiology of the disease. Circulation 124, 1118–1123 (2011). doi:10.1161/CIRCULATIONAHA.111.030379
Collective of authors: A comparative study of the prevalence of abdominal aortic aneurysms in the United Kingdom, Denmark, and Australia. J. Med. Screen. 8, 46–50 (2001). doi:10.1136/jms.8.1.46
Czech Statistical Office (2011) Annual demographical report. http://www.czso.cz/csu/2011edicniplan.nsf/publ/4003-11-r_2011
Greenwald S.E.: Ageing of the conduit arteries. J. Pathol. 211, 157–172 (2007). doi:10.1002/path.2101
O’Rourke M.F., Hashimoto J.: Mechanical factors in arterial aging: a clinical perspective. J. Am. Coll. Cardiol. 50, 1–13 (2007). doi:10.1016/j.jacc.2006.12.050
McEniery C.M., Wilkinson I.B., Avolio A.P.: Age, hypertension and arterial function. Clin. Exp. Pharmacol. Physiol. 34, 665–671 (2007). doi:10.1111/j.1440-1681.2007.04657.x
Arribas S.M., Hinek A., González M.C.: Elastic fibers and vascular structure in hypertension. Pharmacol. Therap. 111, 771–791 (2006). doi:10.1016/j.pharmthera.2005.12.003
Avolio A., Jones D., Tafazzoli-Shadpour M.: Quantification of alternations in structure and function of elastin in the arterial media. Hypertension 32, 170–175 (1998)
Fonck E., Feigl G.G., Fasel J., Sage D., Unser M., Rüfenacht D.A., Stergiopulos N.: Effect of aging on elastin functionality in human cerebral arteries. Stroke 40, 2552–2556 (2009). doi:10.1161/strokeaha.108.528091
Jacob M.P.: Extracellular matrix remodeling and matrix metalloproteinases in the vascular wall during aging and in pathological conditions. Biomed. Pharmacother. 57, 195–202 (2003). doi:10.1016/S0753-3322(03)00065-9
Greenwald S.E., Moore J.E., Rachev A., Kane T.P., Meister J.J.: Experimental investigation of the distribution of residual strains in the artery wall. J. Biomech. Eng. 119, 438–444 (1997). doi:10.1115/1.2798291
Atkinson J.: Age-related medial elastocalcinosis in arteries: mechanisms, animal models, and physiological consequences. J. Appl. Physiol. 105, 1643–1651 (2008). doi:10.1152/japplphysiol.90476.2008
Persy V., D’Haese P.: Vascular calcification and bone disease: the calcification paradox. Trends Mol. Med. 15, 405–416 (2009). doi:10.1016/j.molmed.2009.07.001
Konova E., Baydanoff S., Atanasova M., Velkova A.: Age-related changes in the glycation of human aortic elastin. Exp. Gerontol. 39, 249–254 (2004). doi:10.1016/j.exger.2003.10.003
Haskett D., Johnson G., Zhou A., Utzinger U., Vande Geest J.: Microstructural and biomechanical alternations of the human aorta as a function of age and location. Biomech. Model. Mechanobiol. 9, 725–736 (2010). doi:10.1007/s10237-010-0209-7
Wuyts F.L., Vanhuyse V.J., Langewouters G.J., Decraemer W.F., Raman E.R., Buyle S.: Elastic properties of human aortas in relation to age and atherosclerosis: a structural model. Phys. Med. Biol. 40, 1577–1597 (1995)
Gasser T.C., Ogden R.W., Holzapfel G.A.: Hyperelastic modelling of arterial layers with distributed collagen fibre orientations. J. Roy. Soc. Interface 3, 15–35 (2006). doi:10.1098/rsif.2005.0073
Humphrey J.D., Holzapfel G.A.: Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms. J. Biomech. 45, 805–814 (2012). doi:10.1016/j.jbiomech.2011.11.021
Tsamis A., Rachev A., Stergiopulos N.: A constituent-based model of age-related changes in conduit arteries. Am. J. Physiol. Heart Circ. Physiol. 301, 1286–1301 (2011). doi:10.1152/ajpheart.00570.2010
Lillie M.A., Gosline J.M.: Limits to the durability of arterial elastic tissue. Biomaterials 28, 2021–2031 (2007). doi:10.1016/j.biomaterials.2007.01.016
Cinthio M., Ahlgren A.R., Bergkvist J., Jansson T., Persson H.W., Lindstrom K.: Longitudinal movements and resulting shear strain of the arterial wall. Am. J. Physiol. Heart Circ. Physiol. 291, 394–402 (2006). doi:10.1152/ajpheart.00988.2005
Åstrand H., Stålhand J., Karlsson J., Karlsson M., Sonesson B., Länne T.: In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex. J. Appl. Physiol. 110, 176–187 (2011). doi:10.1152/japplphysiol.00579.2010
Masson I., Beaussier H., Boutouyrie P., Laurent S., Humphrey J.D., Zidi M.: Carotid artery mechanical properties and stresses quantified using in vivo data from normotensive and hypertensive humans. Biomech. Model. Mechanobiol. 10, 867–882 (2011). doi:10.1007/s10237-010-0279-6
Schulze-Bauer C.A.J., Holzapfel G.A.: Determination of constitutive equations for human arteries from clinical data. J. Biomech. 36, 165–169 (2003). doi:10.1016/S0021-9290(02)00367-6
Stalhand J.: Determination of human arterial wall parameters from clinical data. Biomech. Model. Mechanobiol. 8, 141–148 (2009). doi:10.1007/s10237-008-0124-3
Horgan C.O., Saccomandi G.: A description of arterial wall mechanics using limiting chain extensibility constitutive models. Biomech. Model. Mechanobiol. 1, 251–266 (2003). doi:10.1007/s10237-002-0022-z
Destrade M., Ní Annaidh A., Coman C.D.: Bending instabilities of soft biological tissues. Int. J. Solids Struct. 46, 4322–4330 (2009). doi:10.1016/j.ijsolstr.2009.08.017
Kumar, V., Abbas, A.K., Fausto, N., Aster, J.C.: Robbins and Cotran pathologic basis of disease, 8th edn. Elsevier, Philadelphia (2010)
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Horny, L., Adamek, T. & Zitny, R. Age-related changes in longitudinal prestress in human abdominal aorta. Arch Appl Mech 83, 875–888 (2013). https://doi.org/10.1007/s00419-012-0723-4
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DOI: https://doi.org/10.1007/s00419-012-0723-4