Original Paper

Histochemistry and Cell Biology

, Volume 139, Issue 3, pp 403-413

Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice

  • Younghye MoonAffiliated withDepartment of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine
  • , Joo Yeon KimAffiliated withDepartment of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine
  • , So Yoen ChoiAffiliated withDepartment of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine
  • , Hyo Min ChoAffiliated withDepartment of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine
  • , Hyun KimAffiliated withDepartment of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine
  • , Woong SunAffiliated withDepartment of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Ezrin is a member of the ezrin–radixin–moesin (ERM) family of proteins, which link the cytoskeleton and cell membrane. ERM proteins are involved in pivotal cellular functions including cell–matrix recognition, cell–cell communication, and cell motility. Several recent studies have shown that ERM proteins are expressed in specific cell types of the adult rostral migratory stream (RMS). In this study, we found that ERM proteins are expressed highly in the early postnatal RMS and the ventricular zone of embryonic cerebral cortex, suggesting that these proteins may be expressed by neural progenitors. Furthermore, whereas ezrin previously was found to be expressed exclusively by astrocytes of the adult RMS, we found that ezrin-expressing cells also expressed the markers for indicating neuroblasts in vivo and in vitro, and that ezrin expression by neuroblasts decreases progressively as neuroblasts migrate. Using in vitro differentiation of adult neural stem cells, we found that ezrin is expressed by neural stem cells and their progeny (neuroblasts and astrocytes), but not by oligodendrocytic progeny. Collectively our findings demonstrate that adult neural stem cells and neuroblasts express ezrin and that ezrin may be involved in intracellular actin remodeling.

Keywords

Ezrin ERM protein Neuroblast Rostral migratory stream Neural stem cell