Histochemistry and Cell Biology

, Volume 128, Issue 5, pp 457–471

A cluster of gustducin-expressing cells in the mouse stomach associated with two distinct populations of enteroendocrine cells

Original Paper

DOI: 10.1007/s00418-007-0325-3

Cite this article as:
Hass, N., Schwarzenbacher, K. & Breer, H. Histochem Cell Biol (2007) 128: 457. doi:10.1007/s00418-007-0325-3

Abstract

In the gastrointestinal (GI) tract, a variety of digestive processes are continually adapted to the changing composition of ingested foods, which requires a precise chemosensory monitoring of luminal contents. Gustducin-expressing brush cells scattered throughout the GI mucosa are considered candidate sensory cells for accomplishing this task. In this study, we have investigated a large cluster of gustducin-positive cells which is located exactly at the boundary between the fundic and the oxyntic mucosa of the mouse stomach, at the so-called “limiting ridge”. In close association with the candidate chemosensory cluster, we found two populations of enteroendocrine cells: one population containing the satiety regulating hormone ghrelin, the other population comprising serotonin-secreting enterochromaffin cells. The particular arrangement of gustducin-expressing cells and enteroendocrine cells at the limiting ridge suggests a direct interplay between these cell types with immediate implications, not only for digestive processes in the stomach, but also for parameters controlling the satiety status.

Keywords

Gustducin Stomach Chemoreception Serotonin Ghrelin 

Abbreviations

CV

Circumvallate papilla

EC cells

Enterochromaffin cells

ECL cells

Enterochromaffin-like cells

GI

Gastrointestinal

GLP-1

Glucagon-like peptide-1

5-HT

5-Hydroxytryptamin

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Nicole Hass
    • 1
  • Karin Schwarzenbacher
    • 1
  • Heinz Breer
    • 1
  1. 1.University of HohenheimInstitute of PhysiologyStuttgartGermany