Retinal sensitivity measurement over drusen using scanning laser ophthalmoscope microperimetry

  • Y. Takamine
  • Kunihiko Shiraki
  • Mitsuyasu Moriwaki
  • Takaharu Yasunari
  • Tokuhiko Miki
CLINICAL INVESTIGATION

DOI: 10.1007/s004170050079

Cite this article as:
Takamine, Y., Shiraki, K., Moriwaki, M. et al. Graefe's Arch Clin Exp Ophthalmol (1998) 236: 285. doi:10.1007/s004170050079

Abstract 

· Background: Retinal sensitivity over drusen was examined using a scanning laser ophthalmoscope to confirm a previous report of no change in sensitivity over drusen. · Methods: Microperimetry was performed using a scanning laser ophthalmoscope in 23 eyes of 19 subjects. Subject age ranged from 42 to 86 years (mean 68.5 years). Fifty-four drusen bigger than the diameter of a major retinal vein at the optic disc rim were examined, and drusen were classified as soft drusen and other large drusen. · Results: Nine eyes of eight subjects showed a decrease in retinal sensitivity over drusen. The decrease in retinal sensitivity was more than 5 dB less than the sensitivity at a peripheral non-drusen area peripheral to the measurement point. The sensitivity decrease was noted over 15 of 29 large drusen and the decrease was statistically significant (P<0.02). However, no relationship between the size of the drusen and the amount by which sensitivity decreased was found. Nevertheless, a decrease in retinal sensitivity was not seen over any of 25 soft drusen. · Conclusion: Large drusen may influence retinal sensitivity and function.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Y. Takamine
    • 1
  • Kunihiko Shiraki
    • 1
  • Mitsuyasu Moriwaki
    • 1
  • Takaharu Yasunari
    • 1
  • Tokuhiko Miki
    • 1
  1. 1.Department of Ophthalmology, Osaka City University Medical School, 1-5-7, Asahi-machi, Abeno-ku, Osaka, 545 Japan Tel. +81-6-645-2176; fax +81-6-634-3873JP