Abstract
Purpose
To compare global and regional visual field (VF) progression rates and determine clinical factors associated with rapid VF progression in myopic patients with open-angle glaucoma (OAG) with different disc tilt directions.
Methods
The medical records of 182 eyes from 182 myopic OAG patients with progressive VF deterioration during follow-up were analyzed. The rates of change in the mean thresholds of the global and regional VF areas of the horizontal and vertical disc tilt (HDT and VDT) groups were compared using a linear mixed model after controlling for confounding covariates. Clinical factors associated with rapid VF progression in global and regional VF areas were investigated.
Results
The VDT group showed significantly faster VF progression at inferior regional zones than the HDT group (P < 0.05). Based on a multivariate linear mixed model, VDT was associated with faster bi-hemifield VF progression in the GHT map, whereas HDT was associated with faster single-hemifield VF progression.
Conclusions
Myopic OAG eyes show significantly different regional VF progression rates according to disc tilt direction. VDT is an independent predictor of a rapid rate of regional VF progression in both hemifields, whereas HDT predicts rapid regional VF progression in a single hemifield.
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All procedures performed in our study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. As our study is retrospective in nature, formal consent is not required. There is no available identifying information about participants in the article.
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Lee, J.R., Lee, J., Lee, JE. et al. Optic disc tilt direction affects regional visual field progression rates in myopic eyes with open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 254, 2267–2276 (2016). https://doi.org/10.1007/s00417-016-3501-0
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DOI: https://doi.org/10.1007/s00417-016-3501-0