Increased level of platelet P-selectin in nonarteritic anterior ischemic optic neuropathy
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P-selectin receptor is expressed in platelets and endothelial cells in a cell-activation-dependent manner. Platelet P-selectin (CD62) levels may become elevated in a number of vasoocclusive diseases, including arteriosclerosis, atherothrombosis, and diabetes mellitus (DM). Nonarteritic anterior ischemic optic neuropathy (NAION) is associated with a sudden loss of vision due to the vascular insufficiency of ciliary arteries supplying the optic nerve. In this study, our aim was to investigate the presence of increased platelet reactivity in the development of NAION.
Twenty-one NAION patients, 39 healthy control subjects, and 44 patients suffering from diabetes mellitus (DM) were examined in our case-control, pilot study. Platelet activation was investigated by flow cytometric analysis of the mean fluorescence intensity (MFI) of CD62 on platelets. These results were compared among the different study groups.
NAION patients showed considerably although not signifactly (p = 0.2017) higher P-selectin MFI values (71.98 ± 40.30) versus healthy subjects (55.48 ± 20.95), insulin-dependent DM patients (50.02 ± 13.08), and non-insulin-dependent DM subjects (54.72 ± 24.74). However, logistic regression analysis resulted in a statistically significant adjusted effect on the odds of NAION when CD62 MFI values were logarithmically transformed (OR: 3.86, 95 % CI: 1.10 to 13.53, p = 0.0346).
Elevated platelet CD62 positivity may be related to NAION, suggesting a possible role of enlarged platelet activity in the generation of this type of ischemic optic neuropathy.
- Increased level of platelet P-selectin in nonarteritic anterior ischemic optic neuropathy
Graefe's Archive for Clinical and Experimental Ophthalmology
Volume 251, Issue 3 , pp 917-922
- Cover Date
- Print ISSN
- Online ISSN
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- Nonarteritic anterior ischemic optic neuropathy (NAION)
- Arteriae ciliares posteriores breves
- Mean fluorescence intensity
- Flow cytometry
- Industry Sectors
- Author Affiliations
- 1. Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, 4012, Debrecen, Hungary
- 2. Department of Ophthalmology, Hungarian Military Hospital, Budapest, Hungary
- 3. Department of Laboratory Medicine, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, 4012, Debrecen, Hungary
- 4. Kenezy Hospital — Institute of Infectology, Debrecen, Hungary
- 5. Division of Rare Diseases, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, 4012, Debrecen, Hungary