Two-year outcome of photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide for polypoidal choroidal vasculopathy

  • Isao Nakata
  • Akitaka Tsujikawa
  • Kenji Yamashiro
  • Atsushi Otani
  • Sotaro Ooto
  • Yumiko Akagi-Kurashige
  • Naoko Ueda-Arakawa
  • Daisuke Iwama
  • Nagahisa Yoshimura
Retinal Disorders

DOI: 10.1007/s00417-012-2137-y

Cite this article as:
Nakata, I., Tsujikawa, A., Yamashiro, K. et al. Graefes Arch Clin Exp Ophthalmol (2013) 251: 1073. doi:10.1007/s00417-012-2137-y

Abstract

Purpose

To compare the 2-year results after photodynamic therapy (PDT) alone and PDT combined with intravitreal injections of bevacizumab and triamcinolone acetonide (triple therapy) for polypoidal choroidal vasculopathy (PCV).

Methods

We retrospectively reviewed the medical records of 40 consecutive patients (40 eyes) with subfoveal PCV. Of these 40 eyes, 16 were treated with PDT alone and 24 were treated with triple therapy.

Results

The change in visual acuity in the triple therapy group was significantly better than that in the PDT group (P < 0.001). At 24 months, improvement in visual acuity was seen in only two eyes (12.5 %) of the PDT group, while it was seen in ten eyes (41.7 %) of the triple therapy group. Retreatment was given to 12 eyes (75.0 %) in the PDT group and to nine eyes (37.5 %) in the triple therapy group, although the retreatment-free period was significantly longer in the triple therapy group than in the PDT group (P < 0.001). Post-treatment vitreous hemorrhage was seen in only two eyes (12.5 %), all of which were in the PDT group.

Conclusion

Compared with PDT alone, triple therapy appears to reduce the postoperative hemorrhagic complications and recurrences of PCV and to improve the 2-year visual outcomes of PCV.

Keywords

Age-related macular degeneration Bevacizumab Photodynamic therapy Polypoidal choroidal vasculopathy Triamcinolone acetonide 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Isao Nakata
    • 1
  • Akitaka Tsujikawa
    • 1
    • 2
  • Kenji Yamashiro
    • 1
  • Atsushi Otani
    • 1
  • Sotaro Ooto
    • 1
  • Yumiko Akagi-Kurashige
    • 1
  • Naoko Ueda-Arakawa
    • 1
  • Daisuke Iwama
    • 1
  • Nagahisa Yoshimura
    • 1
  1. 1.Department of Ophthalmology and Visual SciencesKyoto University Graduate School of MedicineKyotoJapan
  2. 2.Department of OphthalmologyKyoto University Graduate School of MedicineSakyo-ku, KyotoJapan