Microperimetry as a routine diagnostic test in the follow-up of retinal vein occlusion?
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
In the follow-up of retinal vein occlusions, a patient’s subjective change in vision frequently cannot be confirmed by objective measurements. Furthermore, contradictory results of OCT and distance visual acuity give the impression that current routine diagnostic tests might not be satisfying for patients with retinal vein occlusions. This prospective case series analyses the value of microperimetry as a routine diagnostic test in the follow-up of patients with retinal vein occlusions during therapy.
In a prospective case series, we tested microperimetry as a functional measure in comparison to distance visual acuity, reading ability, and OCT, on 13 patients treated for central or branch retinal vein occlusions. Treatment consisted of intravitreal bevacizumab injections combined with panretinal laser coagulation in cases of peripheral ischemia. If macular edema persisted, bevacizumab injection was repeated, or instead of this intravitreal triamcinolone or focal laser coagulation was applicated. Follow-up ranged from 6–14 months. An interim analysis was performed for the 6-month follow-up.
In the branch retinal vein occlusion group, the average of the retinal thickness measured by OCT was 502.22 μm (±SD 217.75 μm) at baseline and changed to 396.38 ± 154.38 at the 6-month follow-up (p = 0.121). Mean distance visual acuity stayed similar to the study entrance with 0.41 ± 0.34 at the 6-month follow-up (p = 0.944) Mean reading ability improved to 0.51 ± 0.52 at the 6-month follow-up but was not statistically significant (p = 0.435). The mean light sensitivity of microperimetry improved from baseline to the 6-month follow-up: the 40-points group improved from 8.62 ± 5.69 dB to 10.98 ± 5.42 (p = 0.060) and the 8-points group from 6.27 dB to 9.6 dB (p = 0.07) but missed statistical significance. The sector group showed in contrast to this an improvement from 6.02 ± 5.71 dB to 9 ± 6.07 dB (p = 0.025), which was statistically significant. Changes in the central vein occlusion group were not statistically significant but changes for both groups together showed statistical significance.
In the present case series, microperimetry was more convenient to detect, even the subtle functional changes during the disease course of branch retinal vein occlusions than distance and reading visual acuity. This indicates that microperimetry could be a possible valuable tool in the follow-up of branch retinal vein occlusions.
Supplementary Material (0)
- Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, Schneider S (2006) ANCHOR study group: ranibizumab vs. verteporfin for neovascular age-related macular degeneration. N Engl J Med 355:1432–1444 CrossRef
- Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY (2006) Ranibizumab for age-related macular generation. MARINA study. N Engl J Med 355:1419–1431 CrossRef
- Massin P, Bandello F, Garweg JG, Hanssen LL, Harding SP, Larsen M, Mitchell P, Scharp D, Wolf Schnurrbusch UE, Gekkieva M, Weichselberger A, Wolf S (2010) Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study. Diabetes Care 33(11):2399–2405 CrossRef
- Nicholson BP, Schachat AP (2010) A review of clinical trials of anti-VEGF agents for diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 248(7):915–930 CrossRef
- Kampik A, Priglinger S (2008) Intravitreal bevacizumab for the treatment of macular oedema secondary to branch vein occlusion. Br J Ophthalmol 92:351–355 CrossRef
- Jaissle GB, Leitritz M, Gelisken F (2009) One-year results after intravitreal bevacizumab therapy for macular oedema secondary to branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 247:27–33 CrossRef
- Kiss CG, Barisani-Asenbauer T, Simader C, Maca S, Schmidt-Erfurth U (2008) Central visual field impairment during and following cystoid macular oedema. Br J Ophthalmol 92:84–88 CrossRef
- Rohrschneider K, Bueltmann S, Springer C (2008) Use of fundus perimetry (microperimetry) to quantify macular sensitivity. Prog Retinal Eye Res 27:536–548 CrossRef
- Ferris FL, Kassoff A, Bresnick GH, Bailey I (1982) New visual acuity charts for clinical research. Am J Ophthalmol 94:91–96
- Radner W, Willinger U, Obermayer W (1998) Eine neue Lesetafel zur gleichzeitigen Bestimmung von Lesevisus und Lesegeschwindigkeit. Klin Monatsbl Augenheilkd 213:174–181 CrossRef
- Stifter E, Konig F, Lang T, Bauer P, Richter-Müksch S, Velikay-Parel M, Radner W (2004) Reliability of a standardized reading chart system: variance component analysis, test-retest and inter-chart reliability. Graefes Arch Clin Exp Ophthalmol 242:31–39 CrossRef
- Morwood SL (2000) Research strategies for advanced practice nurses. Prentice Hall Health, New Jersey
- du Prel JB, Hommel G, Röhrig B, Blettner M (2009) Confidence interval or p-value?: part 4 of a series on evaluation of scientific publications. Dtsch Arztebl Int 106(19):335–339
- Ach T, Hoch A, Schaal K, Scheuerle AF, Dithmar S (2009) Predictive factors for changes in macular edema in intravitreal bevacizumab therapy for retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. doi:10.1007/s00417-009-1167-6
- Kriechbaum K, Prager F, Geitzenauer W, Benesch T, Schütze C, Simader C, Schmidt-Erfurth U (2009) Association of retinal sensitivity and morphology during antiangiogenic treatment of retinal vein occlusion over one year. Opthalmology 116:2415–2421 CrossRef
- Senturk F, Ozdemir H, Karacorlu M, Karacorlu S, Uysal O (2010) Mircoperimetric changes after intravitreal triamcinolone acetonide injection for macular edema due to central retinal vein occlusion. Retina 30:1254–1261 CrossRef
- Midena E, St V, Convento E, Manfré A, Cavarzeran F, Pilotto E (2007) Microperimetry and fundus autofluorescence in patients with early age- related macular degeneration. Br J Ophthalmol 91:1499–1503 CrossRef
About this Article
- Microperimetry as a routine diagnostic test in the follow-up of retinal vein occlusion?
Graefe's Archive for Clinical and Experimental Ophthalmology
Volume 250, Issue 2 , pp 175-183
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Macular disease
- Retinal vein occlusion
- Industry Sectors
- Author Affiliations
- 1. Department of Ophthalmology, University of Berlin, Charité Virchowklinikum, Augustenburger Platz 1, 13353, Berlin, Germany
- 2. Department of Ophthalmology, University of Duesseldorf, Duesseldorf, Germany
- 3. Department of Cardiology, Helios Hospital Wuppertal, Wuppertal, Germany