Graefe's Archive for Clinical and Experimental Ophthalmology

, Volume 248, Issue 9, pp 1319–1324

Capsule excision and Ologen™ implantation for revision after glaucoma drainage device surgery

  • André Rosentreter
  • Anne C. Mellein
  • Walter W. Konen
  • Thomas S. Dietlein
Glaucoma

DOI: 10.1007/s00417-010-1385-y

Cite this article as:
Rosentreter, A., Mellein, A.C., Konen, W.W. et al. Graefes Arch Clin Exp Ophthalmol (2010) 248: 1319. doi:10.1007/s00417-010-1385-y

Abstract

Background

There is little information available about surgical management after failed glaucoma drainage device (GDD) surgery. We present the outcome of capsule excision after failed GDD surgery compared to capsule excision with additional use of a biodegradable implant (Ologen™, version 2) as a placeholder.

Methods

In an observational comparative case series of 19 patients undergoing excision of the GDD capsule, ten prospectively observed consecutive patients were treated by excision of the capsule, topical mitomycin C application, and implantation of an 10 × 10 × 2 mm-sized Ologen™ implant (group A) while 9 retrospectively observed consecutive patients were treated by excision of the capsule and topical mitomycin C application alone (group B).

Results

Mean preoperative IOP was 29.4 mmHg for group A and 27.6 mmHg for group B, while mean postoperative IOP at the last follow-up (mean follow-up 11.2 (group A) and 8.6 (group B) months) was 17.3 mmHg for group A and 19.3 mmHg for group B (p > 0.05). Follow-up of the two groups demonstrated a significant difference in success rate (log-rank test, p = 0.04) in favor of group A. No further pressure-reducing surgery was necessary in any of the patients in group A, but it was needed in three of nine patients in group B.

Conclusions

Although our study has the limitations of small sample size and observational study design, it shows that further investigation is warranted into the potential of Ologen™ in revision surgery after GDD implantation.

Keywords

Glaucoma drainage deviceBiodegradable implantOlogen™ implantCapsule excision

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • André Rosentreter
    • 1
  • Anne C. Mellein
    • 1
  • Walter W. Konen
    • 1
  • Thomas S. Dietlein
    • 1
    • 2
  1. 1.Department of OphthalmologyUniversity of CologneCologneGermany
  2. 2.University of DüsseldorfDüsseldorfGermany