Graefe's Archive for Clinical and Experimental Ophthalmology

, Volume 243, Issue 12, pp 1200–1205

Intravitreal dexamethasone as adjuvant in the treatment of postoperative endophthalmitis: a prospective randomized trial


  • Ivan M. Gan
    • The Rotterdam Eye Hospital
  • Luana C. Ugahary
    • The Rotterdam Eye Hospital
  • Jaap T. van Dissel
    • Department of Infectious DiseasesUniversity of Leiden Medical Center
  • Eric Feron
    • The Rotterdam Eye Hospital
  • Ed Peperkamp
    • The Rotterdam Eye Hospital
  • Marc Veckeneer
    • The Rotterdam Eye Hospital
  • Paul G. H. Mulder
    • Department of Epidemiology & BiostatisticsErasmus University Medical Center Rotterdam
  • Gert Jan Platenkamp
    • Regional Medical Microbiological Laboratory
    • The Rotterdam Eye Hospital
Clinical Investigation

DOI: 10.1007/s00417-005-0133-1

Cite this article as:
Gan, I.M., Ugahary, L.C., van Dissel, J.T. et al. Graefe's Arch Clin Exp Ophthalmo (2005) 243: 1200. doi:10.1007/s00417-005-0133-1



To study whether intravitreal dexamethasone as adjuvant to intravitreal antibiotics improves the outcome in patients with suspected postoperative bacterial endophthalmitis.


Prospective randomized clinical trial.


Tertiary referral center.

Patient population

Twenty-nine consecutive patients with suspected postoperative bacterial endophthalmitis within 6 weeks of cataract surgery.


Patients underwent a vitreous biopsy followed by intravitreal injection of antibiotics (0.2 mg vancomycin and 0.05 mg gentamicin) and 400 μg dexamethasone or placebo. After 3–4 days the intravitreal injection of antibiotics and dexamethasone or placebo was repeated

Primary outcome measure

Snellen visual acuity at 3 and 12 months after treatment.


In 20/29 patients (69%) the vitreous cultures were positive. 13/29 patients received dexamethasone. Seven patients had a functionally lost eye (final vision of hand movements or less), in four due to retinal detachment. Visual acuity tended to be better in the dexamethasone treated patients than in those given placebo, at both 3 months (P=0.055) and 12 months (P=0.080).


This small prospective, placebo-controlled series showed a trend towards a better visual outcome in patients with suspected bacterial endophthalmitis when treatment with intravitreal antibiotics was combined with intravitreal dexamethasone. Our findings justify a larger multicenter randomized study.



Copyright information

© Springer-Verlag 2005