Pseudoexfoliation syndrome and asymptomatic myocardial dysfunction

  • Lovro Bojić
  • Ratko Ermacora
  • Stojan Polić
  • Milan Ivanišević
  • Zdravko Mandić
  • Veljko Rogošić
  • Mladen Lešin
Clinical Investigation

DOI: 10.1007/s00417-004-1074-9

Cite this article as:
Bojić, L., Ermacora, R., Polić, S. et al. Graefe's Arch Clin Exp Ophthalmol (2005) 243: 446. doi:10.1007/s00417-004-1074-9

Abstract

Background

The purpose of this study was to investigate the frequency of asymptomatic left ventricular dysfunction in patients with pseudoexfoliation syndrome.

Methods

Two-dimensional and pulsed Doppler echocardiography of transmitral flow was performed on 27 patients with pseudoexfoliation syndrome, aged 66.9±5.6 years, and 24 healthy volunteers aged 63.9±6.5 years. Left ventricular (LV) systolic contraction and ejection were assessed by LV ejection fraction (EF) and fractional shortening (FS). LV diastolic filling parameters tested were: early fast diastolic filling (E wave), late diastolic filling (A wave), ratio E/A, velocity time integral E wave (VTIE) and A wave (VTIA), their ratio (VTIE/VTIA), pressure at the end of filling (LVEDP) and a pulmonary capillary wedge pressure (PCWP).

Results

Systolic parameters EF and FS, diastolic filling parameters such as A, LVEDP and PCWP were not significantly different between patients with pseudoexfoliation syndrome and controls (P>0.05). A significant difference (P<0.05) was found with regard to the diastolic filling parameters: E (61.6±15.1 vs 83.7±21.4), ratio E/A (0.8±0.1 vs 1.1±0.2), VTIE (8.6±1.8 vs 9.8±1.9), VTIA (10.3±2.4 vs 7.8±1.6) and ratio VTIA/VTIE (1.2±0.2 vs 0.8±0.2).

Conclusion

Our study suggests the possibility of an association between patients with pseudoexfoliation syndrome and a discrete asymptomatic myocardial diastolic dysfunction.

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Lovro Bojić
    • 1
  • Ratko Ermacora
    • 2
  • Stojan Polić
    • 2
  • Milan Ivanišević
    • 1
  • Zdravko Mandić
    • 3
  • Veljko Rogošić
    • 1
  • Mladen Lešin
    • 1
  1. 1.Department of OphthalmologyClinical Hospital of SplitSplitCroatia
  2. 2.Department of Internal Medicine, Division of CardiologyClinical Hospital of SplitSplitCroatia
  3. 3.Department of Ophthalmology Zagreb Clinical Hospital of the Sisters of MercyZagrebCroatia

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