Journal of Neurology

, Volume 249, Issue 5, pp 584–595

Neurological manifestations of the oculodentodigital dysplasia syndrome

  • Tobias Loddenkemper
  • Kerstin Grote
  • Stefan Evers
  • Michael Oelerich
  • Florian Stögbauer
ORIGINAL COMMUNICATION

DOI: 10.1007/s004150200068

Cite this article as:
Loddenkemper, T., Grote, K., Evers, S. et al. J Neurol (2002) 249: 584. doi:10.1007/s004150200068

Abstract

Oculodentodigital dysplasia (ODDD) (MIM 164200) is a rare autosomal dominant inherited disorder affecting the development of the face, eyes, limbs and dentition. Neurological complications are thought to be occasional manifestations of the disorder. This report illustrates the neurological manifestations by a pedigree of two ODDD patients with spastic paraparesis, cerebral white matter hyperintensity and basal ganglia hypointensity. A systematic review of the English, French, German and Italian literature on ODDD is also provided to summarize the neurological manifestations of the disorder. 243 previously described ODDD cases presented a spectrum of neurological manifestation including spasticity (25), subcortical white matter lesions (9) and basal ganglia changes (6) on MRI. Additional findings consisted of gaze palsy and squinting (28), bladder and bowel disturbances (21), visual loss (20) and blindness (4), hearing loss (15), ataxia (11), nystagmus (9), muscle weakness (5) and paresthesias (3). Neurological manifestations, including spasticity associated with MRI changes, are an underrecognized feature in the ODDD phenotype. A clinical guide to the neurological manifestations of ODDD may assist in the assessment of patients with this condition.

Key words oculodentodigital dysplasiawhite matter lesionssyndactyly

Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Tobias Loddenkemper
    • 1
  • Kerstin Grote
    • 1
  • Stefan Evers
    • 1
  • Michael Oelerich
    • 3
  • Florian Stögbauer
    • 1
  1. 1.Department of Neurology, Westfälische Wilhelms-Universität, Albert-Schweitzer-Str. 33, 48149 Münster, Germany, Tel.: +49-2 51/8 34 80 01, Fax: +49-2 51/8 34 81 81, E-Mail: stogbau@uni-muenster.deGermany
  2. 2.Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, 44195 Ohio, USAUSA
  3. 3.Department of Radiology, Westfälische Wilhelms-Universität, Albert-Schweitzer-Str. 33, 48149 Münster, GermanyGermany