Journal of Neurology

, Volume 247, Issue 3, pp 169–174

Distal myopathies

ENS review

DOI: 10.1007/s004150050557

Cite this article as:
Illa, I. J Neurol (2000) 247: 169. doi:10.1007/s004150050557

Abstract

Distal myopathies are classified according to clinical, histopathological, and genetic patterns into the following: late adult onset type 1, or Welander myopathy, the first recognized distal myopathy with autosomal dominant inheritance and very recently linked to chromosome 2p; late adult onset type 2, or Markesbery-Griggs/Uddmyopathy, autosomal dominant with linkage to chromosome 2q; early adult onset type 1, or Nonaka myopathy, an autosomal recessive disease linked to 9p1-q1 and considered indistinguishable from hereditary inclusion body myopathy; early adult onset type 2, or Miyoshi myopathy, with autosomal recessive inheritance linked to chromosome 2p12-p14; and early adult onset type 3, or Laing myopathy, autosomal dominant with linkage to chromosome 14. Very recently, dysferlin, a novel skeletal muscle gene, has been found mutated in Miyoshi myopathy and also in the limb girdle muscular dystrophy 2B, ¶a disease with a completely different phenotype. This indicates that the classification of the distal and other genetically determined muscle diseases will probably change when these myopathies are understood at the molecular level. For example, it would be reasonable to use the term dysferlinopathies to describe all the diseases due to dysferlin mutations.

Key words Myopathy Distal Vacuoles Dysferlin 

Copyright information

© Steinkopff Verlag 2000

Authors and Affiliations

  • I. Illa
    • 1
  1. 1.Department of Neurology, Institut de Recerca, Hospital de la Sta. Creu i St. Pau, Universitat Autònoma, Sant Antoni M Claret 167, Barcelona 08025, Spain e-mail: iilla@santpau.es, Tel.: +34-93-2919049, Fax: +34-93-2919275ES

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