Journal of Neurology

, Volume 246, Issue 8, pp 706–711

Cerebral computed tomography and electroencephalography compared with neuropsychological findings in systemic lupus erythematosus

  • K. Waterloo
  • R. Omdal
  • E. A. Jacobsen
  • N. E. Kløw
  • G. Husby
  • T. Torbergsen
  • S. I. Mellgren
Original communication

DOI: 10.1007/s004150050436

Cite this article as:
Waterloo, K., Omdal, R., Jacobsen, E. et al. J Neurol (1999) 246: 706. doi:10.1007/s004150050436

Abstract

Central nervous system involvement was evaluated in 36 patients with systemic lupus erythematosus (SLE) using cerebral computed tomography (CT), electroencephalography (EEG), and a neuropsychological test battery. The purpose was to investigate whether brain dysfunction as assessed by comprehensive neuropsychological investigation is associated with findings of routine investigation methods such as CT and EEG which are available in most hospitals. Abnormal EEG was found in 19%, and CT revealed cerebral atrophy in 47% of SLE patients. Few neuropsychological functions were affected by the presence of abnormal EEG, cerebral atrophy, or infarcts. Significant associations were found only between cortical atrophy and impairment of tactile spatial problem-solving and motor dexterity, and between cortical infarcts and motor dexterity in the dominant hand. The value of conventional EEG in assessing cerebral SLE is negligible, except for identifying epileptic activity and focal pathology. Cerebral CT has little relevance in predicting brain dysfunction as established by neuropsychological assessment in SLE, except for detecting cortical atrophy and infarcts.

Key words Systemic lupus erythematosus Electroencephalography Cerebral computed tomography Cognitive function 

Copyright information

© Steinkopff Verlag 1999

Authors and Affiliations

  • K. Waterloo
    • 1
  • R. Omdal
    • 3
  • E. A. Jacobsen
    • 4
  • N. E. Kløw
    • 5
  • G. Husby
    • 6
  • T. Torbergsen
    • 1
  • S. I. Mellgren
    • 1
  1. 1.Department of Neurology, University Hospital, N-9038 Tromsø, Norway e-mail: nevrkw@rito.no, Tel.: + 47-776-26000, Fax: +47-776-27074NO
  2. 2.Department of Psychology, University of Tromsø, N-9037 Tromsø, NorwayNO
  3. 3.Department of Clinical Medicine, University of Tromsø, N-9037 Tromsø, NorwayNO
  4. 4.Department of Radiology, University Hospital, N-9038 Tromsø, NorwayNO
  5. 5.Department of Radiology, Ullevål University Hospital, N-0407 Oslo, NorwayNO
  6. 6.Department of Rheumatology, National University Hospital, N-0027 Oslo, NorwayNO

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