Skip to main content
SpringerLink
Log in

Unusual natalizumab-associated progressive multifocal leukoencephalopathy starting in the brainstem

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Tortorella C, Direnzo V, D’Onghia M, Trojano M (2013) Brainstem PML lesion mimicking MS plaque in a natalizumab-treated MS patient. Neurology 81:1470–1471

    Article  PubMed  Google Scholar 

  2. Vennegoor A, Wattjes MP, van Munster ET, Kriekaart RL, van Oosten BW, Barkhof F, Killestein J, Polman CH (2011) Indolent course of progressive multifocal leukoencephalopathy during natalizumab treatment in MS. Neurology 76:574–576

    Article  CAS  PubMed  Google Scholar 

  3. Yousry TA, Pelletier D, Cadavid D, Gass A, Richert ND, Radue EW, Filippi M (2012) Magnetic resonance imaging pattern in natalizumab-associated progressive multifocal leukoencephalopathy. Ann Neurol 72:779–787

    Article  CAS  PubMed  Google Scholar 

  4. Kuhle J, Gosert R, Buhler R, Derfuss T, Sutter R, Yaldizli O, Radue EW, Ryschkewitsch C, Major EO, Kappos L, Frank S, Hirsch HH (2011) Management and outcome of CSF-JC virus PCR-negative PML in a natalizumab-treated patient with MS. Neurology 77:2010–2016

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Havla J, Berthele A, Kumpfel T, Krumbholz M, Jochim A, Kronsbein H, Ryschkewitsch C, Jensen P, Lippmann K, Hemmer B, Major E, Hohlfeld R (2013) Co-occurrence of two cases of progressive multifocal leukoencephalopathy in a natalizumab “infusion group”. Mult Scler 19:1213–1215

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The reported patient was mentioned in the published paper: “natalizumab “infusion group” with co-occurrence of two cases of progressive multifocal leukoencephalopathy (PML) [5]. This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

Conflicts of Interest

Dr. Havla received speaker honoraria, travel expenses and personal compensations from Merck-Serono, Novartis Pharma and Biogen-Idec. Dr. Hohlfeld is supported by the Deutsche Forschungsgemeinschaft, the KKNMS and has received personal compensations from Bayer Healthcare, Teva Pharma, Merck-Serono, Biogen-Idec, and Novartis Pharma. Dr. Kümpfel has received travel expenses and personal compensations from Bayer Healthcare, Teva Pharma, Merck-Serono, Novartis Pharma, Sanofi-Aventis and Biogen-Idec, as well as grant support from Bayer Healthcare and Novartis Pharma.

Ethical standard

All human studies must state that they have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

Author information

Authors and Affiliations

  1. Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Medical Campus Grosshadern, Marchioninistr. 15, 81377, Munich, Germany

    Joachim Havla, Reinhard Hohlfeld & Tania Kümpfel

  2. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

    Reinhard Hohlfeld

Authors
  1. Joachim Havla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Reinhard Hohlfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tania Kümpfel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Joachim Havla.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Havla, J., Hohlfeld, R. & Kümpfel, T. Unusual natalizumab-associated progressive multifocal leukoencephalopathy starting in the brainstem. J Neurol 261, 232–234 (2014). https://doi.org/10.1007/s00415-013-7191-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-013-7191-9

Keywords

Search

Navigation