, Volume 259, Issue 10, pp 2246-2248
Date: 23 May 2012

Breastfeeding and multiple sclerosis relapses: a meta-analysis

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Dear Sirs,

An increased relapse rate immediately post-partum in multiple sclerosis (MS) patients is well established [1]; however, no consensus has been reached regarding the impact of breastfeeding on post-partum relapse risk. Women with MS make a difficult choice between not restarting disease-modifying drugs and breastfeeding, or restarting therapy and not breastfeeding, or curtailing the duration of breastfeeding. In this study we aimed to meta-analyse all available data to give a more accurate estimate of the impact of breastfeeding on the risk of post-partum relapse.

A comprehensive search of the PubMed database was undertaken using the search terms “breastfeeding” and “multiple sclerosis”. There was no time period restriction. Abstracts of the identified studies were hand-searched to select studies comparing post-partum relapse occurrence in a breastfeeding (BF) versus not breastfeeding group (not BF). Studies were excluded if they were not available in English, an interventional ...