Journal of Neurology

, Volume 259, Issue 3, pp 530–536

Distribution of white matter hyperintensity in cerebral hemorrhage and healthy aging

Authors

  • Yi-Cheng Zhu
    • Department of NeurologyPeking Union Medical College Hospital
    • Department of Neurology CHU LariboisièreAssistance Publique des Hôpitaux de Paris, INSERM U740
    • Unit 708 NeuroepidemiologyINSERM
  • Hugues Chabriat
    • Department of Neurology CHU LariboisièreAssistance Publique des Hôpitaux de Paris, INSERM U740
  • Ophélia Godin
    • Unit 708 NeuroepidemiologyINSERM
    • UPMC Univ Paris 6
  • Carole Dufouil
    • Unit 708 NeuroepidemiologyINSERM
    • UPMC Univ Paris 6
  • Jonathan Rosand
    • Center for Human Genetic ResearchMassachusetts General Hospital, Harvard Medical School
  • Steven M. Greenberg
    • Department of Neurology, Hemorrhagic Stroke Research ProgramMassachusetts General Hospital Stroke Research Center, Harvard Medical School
  • Eric E. Smith
    • Department of Neurology, Hemorrhagic Stroke Research ProgramMassachusetts General Hospital Stroke Research Center, Harvard Medical School
    • Calgary Stroke Program, Department of Clinical NeurosciencesUniversity of Calgary
  • Christophe Tzourio
    • Unit 708 NeuroepidemiologyINSERM
    • UPMC Univ Paris 6
    • Department of Neurology, Hemorrhagic Stroke Research ProgramMassachusetts General Hospital Stroke Research Center, Harvard Medical School
Original Communication

DOI: 10.1007/s00415-011-6218-3

Cite this article as:
Zhu, Y., Chabriat, H., Godin, O. et al. J Neurol (2012) 259: 530. doi:10.1007/s00415-011-6218-3

Abstract

We compared the severity of white matter T2-hyperintensities (WMH) in the frontal lobe and occipital lobe using a visual MRI score in 102 patients with lobar intracerebral hemorrhage (ICH) diagnosed with possible or probable cerebral amyloid angiopathy (CAA), 99 patients with hypertension-related deep ICH, and 159 normal elderly subjects from a population-based cohort. The frontal-occipital (FO) gradient was used to describe the difference in the severity of WMH between the frontal lobe and occipital lobe. A higher proportion of subjects with obvious occipital dominant WMH (FO gradient ≤−2) was found among patients with lobar ICH than among healthy elderly subjects (FO gradient ≤−2: 13.7 vs. 5.7%, p = 0.03). Subjects with obvious occipital dominant WMH were more likely to have more WMH (p = 0.0006) and a significantly higher prevalence of the apolipoprotein E ε4 allele (45.8% vs. 19.4%, p = 0.04) than those who had obvious frontal dominant WMH. This finding is consistent with the relative predilection of CAA for posterior brain regions, and suggests that white matter lesions may preferentially occur in areas of greatest vascular pathology.

Keywords

Intercerebral hemorrhageWhite matter hyperintensityCerebral amyloid angiopathy

Copyright information

© Springer-Verlag 2011