Journal of Neurology

, Volume 258, Issue 10, pp 1763–1774

The role of mitochondria in neurodegenerative diseases

  • Massimiliano Filosto
  • Mauro Scarpelli
  • Maria Sofia Cotelli
  • Valentina Vielmi
  • Alice Todeschini
  • Valeria Gregorelli
  • Paola Tonin
  • Giuliano Tomelleri
  • Alessandro Padovani
Review

DOI: 10.1007/s00415-011-6104-z

Cite this article as:
Filosto, M., Scarpelli, M., Cotelli, M.S. et al. J Neurol (2011) 258: 1763. doi:10.1007/s00415-011-6104-z

Abstract

Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field.

Keywords

Alzheimer’s disease Amyotrophic lateral sclerosis Huntington disease Inclusion body myopathy Mitochondria mtDNA Neurodegenerative disorders Parkinson’s disease 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Massimiliano Filosto
    • 1
  • Mauro Scarpelli
    • 2
  • Maria Sofia Cotelli
    • 1
  • Valentina Vielmi
    • 1
  • Alice Todeschini
    • 1
  • Valeria Gregorelli
    • 1
  • Paola Tonin
    • 2
  • Giuliano Tomelleri
    • 2
  • Alessandro Padovani
    • 1
  1. 1.Clinical Neurology, Section for Neuromuscular Diseases and NeuropathiesUniversity Hospital “Spedali Civili”BresciaItaly
  2. 2.Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement SciencesUniversity of VeronaVeronaItaly