Original Communication

Journal of Neurology

, Volume 258, Issue 12, pp 2163-2167

First online:

Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients

  • Ken SakushimaAffiliated withDepartment of Neurology, Hokkaido University Graduate School of Medicine Email author 
  • , Ichiro YabeAffiliated withDepartment of Neurology, Hokkaido University Graduate School of Medicine
  • , Fumihito NakanoAffiliated withDepartment of Neurology, Asahikawa Red Cross Hospital
  • , Kazuto YoshidaAffiliated withDepartment of Neurology, Asahikawa Red Cross Hospital
  • , Yasutaka TajimaAffiliated withDepartment of Neurology, Sapporo City General Hospital
  • , Hideki HouzenAffiliated withDepartment of Neurology, Obihiro Kosei General Hospital
  • , Yasunori MaruoAffiliated withDepartment of Neurology, Hakodate Municipal Hospital
  • , Hidenao SasakiAffiliated withDepartment of Neurology, Hokkaido University Graduate School of Medicine

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Abstract

The diagnosis of neurosarcoidosis is often difficult; the imaging signs of spinal cord sarcoidosis sometimes mimic those of cervical spondylotic myelopathy, which is common in elderly persons. We examined the characteristics of spinal cord sarcoidosis in Japanese patients with neurosarcoidosis. This case series identified patients with neurosarcoidosis at four general hospitals and one university hospital from April 1998 to September 2010. All diagnoses were based on the diagnostic criteria proposed by Zajicek et al. Seventeen patients (nine men and eight women) were involved: six patients with spinal cord lesions accompanied by cervical spondylosis, five with cerebral lesions, three with cranial nerve lesions, two with meningitis, and one with nerve root lesions. Patients with spinal cord sarcoidosis had a higher onset age, longer duration from onset to diagnosis, reduced leukocytosis in the cerebrospinal fluid (CSF), and lower angiotensin-converting enzyme (ACE) levels in the CSF. The results of this study indicate that diagnosis of spinal cord sarcoidosis requires careful evaluation.

Keywords

Neurosarcoidosis Spinal cord sarcoidosis Cerebrospinal fluid Angiotensin-converting enzyme