Journal of Neurology

, Volume 258, Issue 11, pp 1949–1957

White matter involvement in idiopathic normal pressure hydrocephalus: a voxel-based diffusion tensor imaging study

Authors

    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Nobuhito Abe
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Makoto Saito
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Masahito Takagi
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Yoshiyuki Nishio
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Akiko Hayashi
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Makoto Uchiyama
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Risa Hanaki
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Hirokazu Kikuchi
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Kotaro Hiraoka
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Hiroshi Yamasaki
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Osamu Iizuka
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
  • Atsushi Takeda
    • Department of NeurologyTohoku University Graduate School of Medicine
  • Yasuto Itoyama
    • Department of NeurologyTohoku University Graduate School of Medicine
  • Shoki Takahashi
    • Department of Diagnostic RadiologyTohoku University Graduate School of Medicine
  • Etsuro Mori
    • Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of Medicine
Original Communication

DOI: 10.1007/s00415-011-6038-5

Cite this article as:
Kanno, S., Abe, N., Saito, M. et al. J Neurol (2011) 258: 1949. doi:10.1007/s00415-011-6038-5

Abstract

The aim of this study was to characterise the white matter damage involved in idiopathic normal pressure hydrocephalus (INPH) using diffusion tensor imaging (DTI) and the relationship between this damage and clinical presentation. Twenty patients with INPH, 20 patients with Alzheimer’s disease and 20 patients with idiopathic Parkinson’s disease (as disease control groups) were enrolled in this study. Mean diffusivity (MD) and fractional anisotropy (FA) were determined using DTI, and these measures were analysed to compare the INPH group with the control groups and with certain clinical correlates. On average, the supratentorial white matter presented higher MD and lower FA in the INPH group than in the control groups. In the INPH group, the mean hemispheric FA correlated with some of the clinical measures, whereas the mean hemispheric MD did not. On a voxel-based statistical map, white matter involvement with high MD was localised to the periventricular regions, and white matter involvement with low FA was localised to the corpus callosum and the subcortical regions. The total scores on the Frontal Assessment Battery were correlated with the FA in the frontal and parietal subcortical white matter, and an index of gait disturbance was correlated with the FA in the anterior limb of the left internal capsule and under the left supplementary motor area. DTI revealed the presence of white matter involvement in INPH. Whereas white matter regions with high MD were not related to symptom manifestation, those with low FA were related to motor and cognitive dysfunction in INPH.

Keywords

Idiopathic normal pressure hydrocephalusDiffusion tensor imagingWhite matterAlzheimer’s diseaseParkinson’s disease

Supplementary material

415_2011_6038_MOESM1_ESM.doc (34 kb)
Supplementary material 1 (DOC 34 kb)
415_2011_6038_MOESM2_ESM.doc (31 kb)
Supplementary material 2 (DOC 31 kb)

Copyright information

© Springer-Verlag 2011