Journal of Neurology

, Volume 258, Issue 10, pp 1898–1900

Surviving stiff-person syndrome: a case report

  • Sharmilee Gnanapavan
  • Angela Vincent
  • Gavin Giovannoni
Short Commentary

DOI: 10.1007/s00415-011-6015-z

Cite this article as:
Gnanapavan, S., Vincent, A. & Giovannoni, G. J Neurol (2011) 258: 1898. doi:10.1007/s00415-011-6015-z


Stiff-person syndrome (SPS) is a rare condition of progressive muscular rigidity and spasm, frequently accompanied by other autoimmune conditions, an association which has been further strengthened by the discovery of anti-GAD antibodies and the response of SPS to immunotherapies. Intravenous immunoglobulin (IVIg) is the mainstay therapy. Because of the rarity of the GAD antibody associated conditions, most of the information regarding treatment is case series and individual case reports. Here we describe the 15 year long management of a subject with SPS who has had a favourable outcome.


Stiff-person syndromeGAD antibodyIVIgRituximadSirolimus

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Sharmilee Gnanapavan
    • 1
    • 2
  • Angela Vincent
    • 3
  • Gavin Giovannoni
    • 2
  1. 1.Department of NeuroimmunologyInstitute of NeurologyLondonUK
  2. 2.Neuroscience CentreBarts and The London School of Medicine and DentistryLondonUK
  3. 3.Nuffield Department of Clinical Neurosciences, West WingJohn Radcliffe HospitalOxfordUK