Journal of Neurology

, Volume 258, Issue 4, pp 656–660

Management of punding in Parkinson’s disease: an open-label prospective study

  • A. Fasano
  • L. Ricciardi
  • M. Pettorruso
  • A. R. Bentivoglio
Original Communication

DOI: 10.1007/s00415-010-5817-8

Cite this article as:
Fasano, A., Ricciardi, L., Pettorruso, M. et al. J Neurol (2011) 258: 656. doi:10.1007/s00415-010-5817-8


Punding, a peculiar stereotyped behavior characterized by intense fascination with complex, excessive, non-goal-oriented, repetitive activities, is a quite rare condition complicating Parkinson’s disease (PD). It is triggered by dopaminergic therapy and could have a strong impact on patient quality of life. No study has specifically investigated medical management of this condition, and only a few anecdotal reports have provided therapeutic hints. Given the suggested similarities to drug-induced dyskinesias, we have previously suggested a multistep algorithm for management of punding. We conducted a prospective open-label study on ten PD punders aimed at testing its validity. In two cases, reduction of levodopa therapy was efficacious; amantadine was effective in controlling punding in four cases; in the remaining cases, quetiapine was employed, with mild efficacy in two cases.


AmantadineParkinson’s diseasePundingTherapy



Parkinson’s disease

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • A. Fasano
    • 1
    • 2
  • L. Ricciardi
    • 3
  • M. Pettorruso
    • 4
  • A. R. Bentivoglio
    • 1
  1. 1.Istituto di NeurologiaUniversità Cattolica del Sacro Cuore Largo Agostino Gemelli, 8RomeItaly
  2. 2.Neuromed InstitutePozzilliItaly
  3. 3.Department of Neurosciences, Psychiatry and Anaesthesiological ScienceUniversity of MessinaMessinaItaly
  4. 4.Department of PsychiatryCatholic University of Sacred HeartRomeItaly