Journal of Neurology

, Volume 257, Issue 10, pp 1703–1707

Influence of apolipoprotein E plasma levels and tobacco smoking on the induction of neutralising antibodies to interferon-beta

Authors

    • CEDOC, Departamento de Bioquímica, Faculdade de Ciências MédicasUniversidade Nova de Lisboa
    • Departamento de NeurociênciasCentro Hospitalar de Lisboa-Central
  • Klaus Bendtzen
    • Institute for Inflammation Research IIR7521Rigshospitalet National University Hospital
  • Maria J. Cascais
    • CEDOC, Departamento de Bioquímica, Faculdade de Ciências MédicasUniversidade Nova de Lisboa
  • Rui Pedrosa
    • Departamento de NeurociênciasCentro Hospitalar de Lisboa-Central
  • Véronique Ferret-Sena
    • Departamento de FisiologiaCentro de Investigação Interdisciplinar Egas Moniz
  • Elisa Campos
    • CEDOC, Departamento de Bioquímica, Faculdade de Ciências MédicasUniversidade Nova de Lisboa
Original Communication

DOI: 10.1007/s00415-010-5606-4

Cite this article as:
Sena, A., Bendtzen, K., Cascais, M.J. et al. J Neurol (2010) 257: 1703. doi:10.1007/s00415-010-5606-4

Abstract

Interferon-beta (IFN-beta) therapy for multiple sclerosis (MS) is associated with a potential for induction of neutralizing antibodies (NAbs). Because immune reactivity depends on changes in lipoprotein metabolism, we investigated whether plasma lipoprotein profiles could be associated with the development of NAbs. Thirty-one female MS patients treated with subcutaneously administered IFN-beta were included. Demographic and clinical characteristics were compared between NAbs response groups using t tests for continuous and logistic regression analysis and Fisher’s exact tests for categorical data, respectively. Multivariate logistic regression was used to evaluate the effect of potential confounders. Patients who developed NAbs had lower apoE levels before treatment, 67 (47–74) mg/L median (interquartile range), and at the moment of NAb analysis, 53 (50–84) mg/L, in comparison to those who remained NAb-negative, 83 (68–107) mg/L, P = 0.03, and 76 (66–87) mg/L, P = 0.04, respectively. When adjusting for age and smoking for a one-standard deviation decrease in apoE levels, a 5.6-fold increase in the odds of becoming NAb-positive was detected: odds ratios (OR) 0.18 (95% CI 0.04–0.77), P = 0.04. When adjusting for apoE, smoking habit became associated with NAb induction: OR 5.6 (95% CI 1.3–87), P = 0.03. These results suggest that apoE-containing lipoprotein metabolism and, possibly, tobacco smoking may be associated with risk of NAb production in female MS patients treated with IFN-beta.

Keywords

Multiple sclerosis Interferon-beta Neutralising antibodies Lipoproteins Apolipoprotein E Tobacco smoking

Copyright information

© Springer-Verlag 2010