Journal of Neurology

, Volume 257, Issue 4, pp 603–608

Transient gender-related effects in Parkinson’s disease patients with subthalamic stimulation

  • Luigi Michele Romito
  • Fiorella Maria Contarino
  • Alberto Albanese
Original Communication

DOI: 10.1007/s00415-009-5381-2

Cite this article as:
Romito, L.M., Contarino, F.M. & Albanese, A. J Neurol (2010) 257: 603. doi:10.1007/s00415-009-5381-2

Abstract

Little is known about the gender-related long-term efficacy and safety after subthalamic nucleus deep brain stimulation (STN DBS) implant for Parkinson’s disease (PD), although some differences could be expected as recently stated in a short-term report. We assessed the possible gender-related differences in clinical outcome and disease progression along a 5-year period after STN DBS for PD. A prospective cohort of PD patients who underwent STN DBS and reached the 5-year follow-up (FU) was considered. Clinical outcome, disease progression and side effects were assessed at baseline and 1, 3, and 5 years after surgery. Eleven men and nine women were included in the study. At baseline, no inter-gender difference of age at implant, disease duration and severity or levodopa responsiveness was detected. A higher motor responsiveness in men compared to women was detected only at 1-year FU: this difference was mainly related to worse lower limb akinesia and gait score in women. The difference was not confirmed at 3 and 5 years. Antiparkinsonian drugs reduction, improvement in motor fluctuations and dyskinesias, functional measures and progression of underlying PD, were comparable in both groups. Women had persistent adverse events comparable to men. The present long-term observation confirms the occurrence of slight gender-related differences in PD patients treated with STN DBS, indicating a transient poorer outcome in women. Further observational time and a wider number of patients are needed to better analyze the dimension of long-term gender-related differences.

Keywords

Parkinson’s diseaseDeep brain stimulationGenderSubthalamusSurgeryMovement disorders

Abbreviations

DBS

Deep brain stimulation

IPG

Implantable pulse generator

LEDD

Levodopa-equivalent daily dose

PD

Parkinson’s disease

STN

Subthalamic nucleus

TEED

Total electrical energy delivered

UPDRS

Unified Parkinson’s Disease Rating Scale

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Luigi Michele Romito
    • 1
    • 2
  • Fiorella Maria Contarino
    • 3
    • 4
  • Alberto Albanese
    • 1
    • 2
  1. 1.Università Cattolica del Sacro CuoreMilanItaly
  2. 2.Neurology DepartmentFondazione IRCCS Istituto Neurologico “Carlo Besta”MilanItaly
  3. 3.Istituto di NeurologiaUniversità Cattolica del Sacro CuoreRomaItaly
  4. 4.Department of Neurology, H2-222Academic Medical CentreAmsterdamThe Netherlands