Journal of Neurology

, Volume 257, Issue 3, pp 383–391

REM sleep behaviour disorder and visuoperceptive dysfunction: a disorder of the ventral visual stream?

  • Ana Marques
  • Kathy Dujardin
  • Muriel Boucart
  • Delphine Pins
  • Marie Delliaux
  • Luc Defebvre
  • Philippe Derambure
  • Christelle Monaca
Original Communication

DOI: 10.1007/s00415-009-5328-7

Cite this article as:
Marques, A., Dujardin, K., Boucart, M. et al. J Neurol (2010) 257: 383. doi:10.1007/s00415-009-5328-7

Abstract

In idiopathic rapid eye movement sleep behaviour disorder (RBD), an association with visuoperceptive disorders has been described. However, such an association has not been clearly established in RBD secondary to Parkinson’s disease (PD). We compared visuoperceptive function in four groups of non-demented patients (parkinsonian patients with or without RBD, patients with idiopathic RBD and control participants) via a procedure enabling the analysis of the various components of visual information processing and in order to answer the following question: is RBD associated with visuoperceptive and/or attentional disorders in PD and, if so, where is the dysfunction located along the visual pathway? Sensorial aspects of visual information were evaluated using a contrast sensitivity test, perceptual aspects were assessed using a contour-based object identification test and visual attention was measured in an attentional capture paradigm. The diagnosis of RBD was confirmed by polysomnography. We observed a higher object identification threshold (OIT) (1) in PD patients with RBD compared with PD patients without RBD and with controls and (2) in idiopathic RBD patients compared with controls. There were no significant OIT differences between PD patients with RBD and idiopathic RBD patients or between PD patients without RBD and controls. We did not find any significant inter-group differences in any of the other visuoperceptive tests. RBD, idiopathic or secondary to PD, is associated with perceptual closure dysfunction. Our results suggest that this perceptual dysfunction is specifically associated with RBD and may be related to a non-dopaminergic impairment.

Keywords

REM sleep behaviour disorder Parkinson’s disease Visuoperception Perceptual closure 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Ana Marques
    • 1
  • Kathy Dujardin
    • 2
  • Muriel Boucart
    • 3
  • Delphine Pins
    • 3
  • Marie Delliaux
    • 2
  • Luc Defebvre
    • 2
  • Philippe Derambure
    • 1
  • Christelle Monaca
    • 1
  1. 1.Service de Neurophysiologie Clinique, Unité des troubles de la veille et du sommeil, EA 2683, IFR 114Hôpital Roger Salengro, CHRU de LilleLille cedexFrance
  2. 2.Service de Pathologie du Mouvement, EA 2683, IFR 114Hôpital Roger Salengro, CHRU LilleLille cedexFrance
  3. 3.Laboratoire Neurosciences Fonctionnelles et Pathologies, CNRS UMR 8160, IFR 114Université Lille 2, CHRU LilleLille cedexFrance