Journal of Neurology

, Volume 255, Issue 12, pp 1872–1880

Weight loss in neurodegenerative disorders

Authors

    • Leiden University Medical CentreDept. of Neurology, K-05-Q 110
  • M. A. van der Marck
    • Dept. of NeurologyRadboud University Nijmegen Medical Centre
  • H. Pijl
    • Dept. of Endocrinology and Metabolic, DiseasesLeiden University Medical Centre
  • M. G. M. Olde Rikkert
    • Dept. of Geriatric MedicineRadboud University Nijmegen Medical Centre
  • B. R. Bloem
    • Dept. of NeurologyRadboud University Nijmegen Medical Centre
  • R. A. C. Roos
    • Leiden University Medical CentreDept. of Neurology, K-05-Q 110
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-009-0062-8

Cite this article as:
Aziz, N.A., van der Marck, M.A., Pijl, H. et al. J Neurol (2008) 255: 1872. doi:10.1007/s00415-009-0062-8

Abstract

Unintended weight loss frequently complicates the course of many neurodegenerative disorders and can contribute substantially to both morbidity and mortality. This will be illustrated here by reviewing the characteristics of unintended weight loss in the three major neurodegenerative disorders: Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. A common denominator of weight loss in these neurodegenerative disorders is its typically complex pathophysiology. Timely recognition of the underlying pathophysiological process is of crucial importance, since a tailored treatment of weight loss can considerably improve the quality of life. This treatment is, primarily, comprised of a number of methods of increasing energy intake. Moreover, there are indications for defects in the systemic energy homeostasis and gastrointestinal function, which may also serve as therapeutic targets. However, the clinical merits of such interventions have yet to be demonstrated.

Key words

weight lossneurodegenerative disordersAlzheimer’s diseaseParkinson’s diseaseHuntington’s disease

Copyright information

© Steinkopff-Verlag 2009