Clinical features and associated syndromes of mal de debarquement
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To investigatethe clinical features and naturalhistory of mal de debarquement(MdD).
Retrospective casereview with follow-up questionnaireand telephone interviews.
University Neurotology Clinic.
Patients seen between1980 and 2006 who developed apersistent sensation of rocking orswaying for at least 3 days after exposureto passive motion.
Main outcome measure
Clinical features,diagnostic testing, and questionnaireresponses.
Of 64 patients(75 % women) identifiedwith MdD, 34 completed follow-upquestionnaires and interviews in2006. Most patients had normalneurological exams, ENGs andbrain MRIs. The average age of thefirst MdD episode was 39 ± 13years. A total of 206 episodes wereexperienced by 64 patients. Ofthese, 104 episodes (51 %) lasted> 1 month; 18 %, > 1 year; 15 %, > 2years; 12 %, > 4 years, and 11 %, > 5years. Eighteen patients (28 %) subsequentlydeveloped spontaneousepisodes of MdD-like symptomsafter the initial MdD episode.There was a much higher rate ofmigraine in patients who went onto develop spontaneous episodes(73 %) than in those who did not(22 %). Subsequent episodes werelonger than earlier ones in mostpatients who had multiple episodes.Re-exposure to passivemotion temporarily decreasedsymptoms in most patients (66 %).Subjective intolerance to visualmotion increased (10 % to 66 %)but self-motion sensitivity did not(37 % to 50 %) with onset of MdD.
The majority of MdDepisodes lasting longer than 3 daysresolve in less than one year but theprobability of resolution declineseach year. Many patients experiencemultiple MdD episodes. Somepatients develop spontaneousepisodes after the initial motiontriggeredepisode with migrainebeing a risk factor.
- Bles, (1983) Acta Otolaryngol 95: pp. 576 CrossRef
- Britton, (1993) ExpBrain Res 94: pp. 143
- Brown, (1987) Am J Otolaryngol 8: pp. 219 CrossRef
- Flanagan, (2004) J Vest Res 14: pp. 335
- Gordon, (1995) J Vest Res 5: pp. 363 CrossRef
- Gordon, (1992) BMJ 304: pp. 544
- Hain, (1999) ArchOtolaryngol Head Neck Surg 125: pp. 615
- Headache Classification Subcommitteeof the International Headache Society(2004) The International Classificationof Headache Disorders 2nd edition.Cephalalgia 24(Suppl 1):1–160
- Irwin, (1881) Lancet 2: pp. 907 CrossRef
- Jeka, (1998) J Neurophysiol 79: pp. 1661
- Kavounoudias, (2001) J Physiol 532: pp. 869 CrossRef
- Lewis, (2004) Neurology 63: pp. 1983
- Lipton, (2007) Neurology 68: pp. 343 CrossRef
- Mair, (1996) J Audiol Med 5: pp. 21
- Mergner, (2003) ProgBrain Res 142: pp. 189 CrossRef
- Moeller, (2007) J Neurol 254: pp. 813 CrossRef
- Peterka, (1995) Exp Brain Res 105: pp. 101 CrossRef
- Reason, (1978) Journal of the Royal Society ofMedicine 71: pp. 819
- Clinical features and associated syndromes of mal de debarquement
Journal of Neurology
Volume 255, Issue 7 , pp 1038-1044
- Cover Date
- Print ISSN
- Online ISSN
- D. Steinkopff-Verlag
- Additional Links
- mal de debarquement
- vestibular adaptation
- motion sensitivity
- visual motion
- Industry Sectors
- Author Affiliations
- 1. Dept. of Neurology, University of California, 710 Westwood Plaza, 951769, Los Angeles, CA 90095, USA
- 2. Dept. of Statistics, University of California, 8/25 Math Sciences Building, 95/554, Los Angeles, CA 90095-1554, USA
- 3. Dept. of Human Genetics, University of CaliforniaUCLA Hum Genetics, 957088, 6357A Gonda Cntr, Los Angeles, CA 90095-7088, USA