Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment
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- Hanse, M.C.J., van’t Veer, M.B., van Lom, K. et al. J Neurol (2008) 255: 828. doi:10.1007/s00415-008-0710-4
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Leptomeningeal involvement in patients with CLL is relatively rare and the prognosis is usually considered to be poor. The authors reviewed all CLL patients treated in a tertiary referral center to assess the incidence and outcome of leptomeningeal involvement (LI) in CLL. They found an incidence of 1–2% of LI. Most of the patients with LI had a longterm survival, despite failure to clear the cerebrospinal fluid from tumor cells.