Journal of Neurology

, Volume 254, Supplement 5, pp 41–48

Dementia in Parkinson's disease

  • Maria J. Martí
  • Eduardo Tolosa
  • Andres de la Cerda
Article

DOI: 10.1007/s00415-007-5007-5

Cite this article as:
Martí, M.J., Tolosa, E. & de la Cerda, A. J Neurol (2007) 254(Suppl 5): 41. doi:10.1007/s00415-007-5007-5
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Abstract

Dementia is a frequent complication of Parkinson's disease (PD), usually occurring late in the course of the illness. Clinically, dementia in PD often is characterized by an insidious onset and slowly progressive cognitive decline, with predominant dysexecutive syndrome accompanied by a variety of behavioral symptoms. The pathological substrate of dementia in PD is a matter of controversy. The common co-occurrence of alpha-synuclein and Alzheimer disease-type pathology suggests that both may play an important role. Dysfunction of different monoamine transmitters has also been implicated in the cognitive deterioration associated with PD but reduced cholinergic activity in the cortex is thought to account for the predominant mechanism in the development of dementia. Recent studies suggest that cholinesterase inhibitors might be useful in the treatment of dementia of PD.

Key words

Parkinson's disease dementia executive dysfunction cortical Lewy body cholinesterase inhibitor 

Copyright information

© Steinkopff-Verlag 2007

Authors and Affiliations

  • Maria J. Martí
    • 1
  • Eduardo Tolosa
    • 1
    • 2
  • Andres de la Cerda
    • 1
  1. 1.Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociencies, Institut d'Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic Universitari, University of BarcelonaBarcelonaSpain
  2. 2.Institut Clinic de Neurociencias, Hospital Clínic, Escala 8, Planta 4University of BarcelonaBarcelonaSpain

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