Journal of Neurology

, Volume 254, Supplement 2, pp II73-II76

First online:

Neuropsychiatric syndromes associated with multiple sclerosis

  • Anthony FeinsteinAffiliated withDept. of Psychiatry, University of Toronto, Sunnybrook Health Sciences Centre Email author 

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Multiple sclerosis is associated with diverse behavioral changes. Rates of major depression approach 50% over the course of patients' lives, rates of bipolar disorder and psychosis are twice as common when compared to rates in the general population and pseudobulbar affect will afflict one in ten patients. However, these disorders often respond well to pharmacologic treatment and in the case of major depression, some forms of psychotherapy too. This article summarizes these mental state changes, their pathogenesis and treatment. Correct diagnosis and treatment can substantially improve the quality of life for MS patients.

Key words

depression mania psychosis personality multiple sclerosis treatment