Journal of Neurology

, Volume 254, Issue 4, pp 488–492

Two subtypes of optic-spinal form of multiple sclerosis in Japan: clinical and laboratory features

Authors

    • Dept. of Neurology TohokuUniversity School of Medicine
  • Toshiyuki Fukazawa
    • Dept. of NeurologyNishi Maruyama Hospital
  • Kohei Ota
    • Dept. of NeurologyTokyo Women's Medical University
  • Chiyoko Nohara
    • Dept. of NeurologyTokyo Metropolitan Ebara Hospital
  • Yoko Warabi
    • Dept. of NeurologyTokyo Metropolitan Neurological Hospital
  • Takashi Ohashi
    • Dept. of NeurologyTokyo Women's Medical University
  • Isabelle Miyazawa
    • Dept. of Neurology TohokuUniversity School of Medicine
  • Kazuo Fujihara
    • Dept. of Neurology TohokuUniversity School of Medicine
  • Yasuto Itoyama
    • Dept. of Neurology TohokuUniversity School of Medicine
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-006-0400-z

Cite this article as:
Nakashima, I., Fukazawa, T., Ota, K. et al. J Neurol (2007) 254: 488. doi:10.1007/s00415-006-0400-z

Abstract

Seventy-seven cases of the optic-spinal form of multiple sclerosis (OSMS) were collected from 6 institutes in 3 cities of Japan, and the clinical and MRI features were analyzed. Two-thirds of the OSMS patients had longitudinally extensive spinal cord MRI lesions (LESL), and had clinical features similar to those of relapsing neuromyelitis optica which often causes severe disability. In contrast, OSMS patients without LESL tended to have milder disease and had some feature commonly seen in the conventional form of MS. The percentage of OSMS without LESL in total OSMS has recently been increasing. The present study suggests that LESL is crucially important for distinguishing the two subtypes of OSMS.

Key words

multiple sclerosis optic spinal form neuromyelitis optica MRI

Copyright information

© Steinkopff-Verlag 2007