Journal of Neurology

, Volume 254, Issue 7, pp 838–845

Regional patterns of cerebral glucose metabolism in spinocerebellar ataxia type 2, 3 and 6

A voxel-based FDG-positron emission tomography analysis

DOI: 10.1007/s00415-006-0383-9

Cite this article as:
Wang, PS., Liu, RS., Yang, BH. et al. J Neurol (2007) 254: 838. doi:10.1007/s00415-006-0383-9


The purpose of this study was to investigate the regional patterns of cerebral metabolic deficits by voxel-based FDGPET analysis in patients with distinct spinocerebellar ataxia (SCA) genotypes, including SCA type 2 (SCA2), SCA3, and SCA6. Nine patients with SCA2, 12 with SCA3, seven with SCA6, and 23 healthy control subjects were recruited. The clinical severity of the patients’ cerebellar ataxia was evaluated according to the International Cooperative Ataxia Rating Scale. The brain glucose metabolism was evaluated with 2- [fluorine 18]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography. Group data were analyzed and compared by voxelbased analysis. In SCA2, FDG utilization was significantly reduced in the cerebellum, pons, parahippocampal gyrus and frontal cortex. In SCA3, FDG metabolism in the cerebellum, parahippocampal gyrus of the limbic system, and lentiform nucleus was decreased. In SCA6, FDG metabolism was diminished in the cerebellum and the frontal and prefrontal cortices. On group comparisons, while all SCAs have impaired cerebellar functions, the cerebellar FDG metabolism was most severely compromised in SCA2. Instead, the FDG metabolism in the lentiform nucleus and medulla was characteristically worst in SCA3. There was no brainstem involvement in SCA6.

Key words

Positron emission tomography spinocerebellar ataxia type 2 spinocerebellar ataxia type 3 spinocerebellar ataxia type 6 

Copyright information

© Steinkopff-Verlag 2007

Authors and Affiliations

  • P.-S. Wang
    • 1
    • 2
    • 3
  • R.-S. Liu
    • 4
  • B.-H. Yang
    • 4
  • B.-W. Soong
    • 1
    • 2
    • 5
  1. 1.The Neurological InstituteTaipei Veterans General Hospital Taiwan
  2. 2.Dept. of NeurologyNational Yang-Ming University School of MedicineTaipeiTaiwan
  3. 3.Dept. of NeurologyTaipei Municipal Gan-Dau HospitalTaiwan
  4. 4.Dept. of Nuclear MedicineNational PET/Cyclotron Center, Taipei Veterans General HospitalTaiwan
  5. 5.The Neurological InstituteTaipei Veterans General HospitalTaipeiTaiwan

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