Journal of Neurology

, Volume 254, Issue 3, pp 327–332

Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization

  • Antoine Dunac
  • Christian Frelin
  • Margherita Popolo-Blondeau
  • Marcel Chatel
  • Marie H. Mahagne
  • Patrick J.-M. Philip
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-006-0362-1

Cite this article as:
Dunac, A., Frelin, C., Popolo-Blondeau, M. et al. J Neurol (2007) 254: 327. doi:10.1007/s00415-006-0362-1

Abstract

Background

A spontaneous mobilization of Peripheral Blood-Mononuclear CD34+ Cells (PB-MNC-CD34+) has recently been reported in human myocardial infarction and found to be related to improved heart function and survival. However, nothing is known regarding a possible relation between PB-MNC-CD34+ mobilization and neurological recovery in human acute cerebral ischemia.

Methods and Results

PB-MNC-CD34+ were determined daily after an acute cerebral ischemic attack for 14 days in 25 patients with acute ischemic stroke and compared with controls. Results indicated that stroke was followed by large and bursting mobilizations of PB-MNC-CD34+. The amplitude of the mobilizations was similar to those observed in Granulocyte Colony Stimulating Factor (G-CSF) conditioned aplastic patients following myeloablative therapy before leukapheresis and autologous bone graft. The extent of PB-MNC-CD34+ mobilization in each patient was directly related to neurological and functional recoveries as assessed by NIH Stroke Scale, and modified Rankin Scale respectively.

Conclusions

The mobilization of PB-MNC-CD34+ cells might be predictive of neurological and functional recovery.

Keywords

angiogenesisneurological recoveryfunctional recoverystem cell plasticitystroke

Copyright information

© Steinkopff Verlag Darmstadt 2007

Authors and Affiliations

  • Antoine Dunac
    • 1
    • 2
    • 3
  • Christian Frelin
    • 2
    • 4
  • Margherita Popolo-Blondeau
    • 3
  • Marcel Chatel
    • 2
    • 3
  • Marie H. Mahagne
    • 2
    • 3
  • Patrick J.-M. Philip
    • 2
    • 3
    • 5
  1. 1.Dept. of Neurology (Stroke Unit)University Hospital PasteurNice CedexFrance
  2. 2.NiceFrance
  3. 3.CHRU Nice, Service de Neurologie, Stroke unitNiceFrance
  4. 4.Université de Nice Sophia AntipolisFrance
  5. 5.Dept. d’hématologieCHRU Nice, Unité d’Exploration Fonctionnelle, Cellulaire et Tissulaire (UEFCT)NiceFrance