Journal of Neurology

, Volume 254, Issue 3, pp 327-332

First online:

Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization

  • Antoine DunacAffiliated withDept. of Neurology (Stroke Unit), University Hospital PasteurCHRU Nice, Service de Neurologie, Stroke unit Email author 
  • , Christian FrelinAffiliated withUniversité de Nice Sophia Antipolis
  • , Margherita Popolo-BlondeauAffiliated withCHRU Nice, Service de Neurologie, Stroke unit
  • , Marcel ChatelAffiliated withCHRU Nice, Service de Neurologie, Stroke unit
  • , Marie H. MahagneAffiliated withCHRU Nice, Service de Neurologie, Stroke unit
  • , Patrick J.-M. PhilipAffiliated withCHRU Nice, Service de Neurologie, Stroke unitDept. d’hématologie, CHRU Nice, Unité d’Exploration Fonctionnelle, Cellulaire et Tissulaire (UEFCT)

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A spontaneous mobilization of Peripheral Blood-Mononuclear CD34+ Cells (PB-MNC-CD34+) has recently been reported in human myocardial infarction and found to be related to improved heart function and survival. However, nothing is known regarding a possible relation between PB-MNC-CD34+ mobilization and neurological recovery in human acute cerebral ischemia.

Methods and Results

PB-MNC-CD34+ were determined daily after an acute cerebral ischemic attack for 14 days in 25 patients with acute ischemic stroke and compared with controls. Results indicated that stroke was followed by large and bursting mobilizations of PB-MNC-CD34+. The amplitude of the mobilizations was similar to those observed in Granulocyte Colony Stimulating Factor (G-CSF) conditioned aplastic patients following myeloablative therapy before leukapheresis and autologous bone graft. The extent of PB-MNC-CD34+ mobilization in each patient was directly related to neurological and functional recoveries as assessed by NIH Stroke Scale, and modified Rankin Scale respectively.


The mobilization of PB-MNC-CD34+ cells might be predictive of neurological and functional recovery.


angiogenesis neurological recovery functional recovery stem cell plasticity stroke