Does modafinil enhance activity of patients with myotonic dystrophy?
- A.R. WintzenAffiliated withDept. of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, LUMC 9600 Email author
- , G.J. LammersAffiliated withDept. of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, LUMC 9600
- , J.G. van DijkAffiliated withDept. of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, LUMC 9600
We performed a double-blind placebo-controlled crossover study in 13 patients with myotonic dystrophy to address the question whether modafinil, known to improve hypersomnolence in myotonic dystrophy, may improve levels of activity as well. We used the Epworth Sleepiness Scale as a measure of hypersomnolence and a structured interview of the patient and the partner or housemate as a measure of activity. We additionally used a restricted form of the RAND-36 to relate a possible improvement of activity to perceived general health. We confirmed earlier positive findings of modafinil regarding reduced somnolence (p = 0.015), but no significant effects were seen regarding activity levels (p = 0.2 for patients’ self-reports and 0.5 for partners’ reports).
Keywordsmyotonic dystrophy modafinil hypersomnolence levels of activity RAND-36
- Does modafinil enhance activity of patients with myotonic dystrophy?
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Journal of Neurology
Volume 254, Issue 1 , pp 26-28
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- myotonic dystrophy
- levels of activity
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