Journal of Neurology

, Volume 253, Issue 6, pp 741–745

Elevated inflammatory laboratory parameters in spontaneous cervical artery dissection as compared to traumatic dissection

A retrospective case–control study

DOI: 10.1007/s00415-006-0109-z

Cite this article as:
Forster, K., Poppert, H., Conrad, B. et al. J Neurol (2006) 253: 741. doi:10.1007/s00415-006-0109-z


Several studies have reported infection as a possible risk factor for cervical artery dissection (CAD). We retrospectively analyzed several inflammatory parameters of CAD patients with the aim of detecting differences between spontaneous (n = 25) and traumatic (n = 18) CAD. In this case–control study, we observed significantly higher absolute leucocyte values (10.3 versus 8.1 G/L; p = 0.02) as well as an elevated frequency of leucocytosis (64% versus 28%; p = 0.02) and elevated CRP (60% versus 28%; p = 0.04) in patients without a history of trauma ("spontaneous" CAD) compared with patients with traumarelated CAD. As the elevated inflammatory laboratory parameters were not associated with an elevated infection rate, these findings imply a role of an acute inflammation as a pathogenetic factor in spontaneous CAD. The cause and mechanism of the inflammatory process remain unknown.

Key words

dissection inflammation leucocytosis trauma 

Copyright information

© Steinkopff-Verlag 2006

Authors and Affiliations

  1. 1.Department of NeurologyKlinikum Rechts der Isar, Technical University of MunichMünchenGermany

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