Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding
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- Happe, S., Pirker, W., Klösch, G. et al. J Neurol (2003) 250: 83. doi:10.1007/s00415-003-0957-8
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We used single photon emission computed tomography (SPECT) to study striatal [123I]β-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [123I]β-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients.