Journal of Neurology

, Volume 250, Issue 1, pp 83–86

Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding

Authors

  • Svenja Happe
    • Department of Clinical Neurophysiology, Robert-Koch-Strasse 40, 37075 Goettingen, Germany. shappe@gwdg.de
  • Walter Pirker
    • Department of Clinical Neurology, University of Vienna, Austria
  • Gerhard Klösch
    • Department of Clinical Neurology, University of Vienna, Austria
  • Cornelia Sauter
    • Department of Clinical Neurology, University of Vienna, Austria
  • Josef Zeitlhofer
    • Department of Clinical Neurology, University of Vienna, Austria
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-003-0957-8

Cite this article as:
Happe, S., Pirker, W., Klösch, G. et al. J Neurol (2003) 250: 83. doi:10.1007/s00415-003-0957-8

Abstract.

We used single photon emission computed tomography (SPECT) to study striatal [123I]β-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [123I]β-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients.

Key words [123I]β-CITParkinson's disease (PD)periodic leg movements during sleep (PLMS)polysomnographySPECT
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Copyright information

© Steinkopff Verlag 2003