, Volume 250, Issue 1, pp 83-86

Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding

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Abstract.

We used single photon emission computed tomography (SPECT) to study striatal [123I]β-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [123I]β-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients.

Received: 26 April 2002, Received in revised form: 21 August 2002, Accepted: 29 August 2002
Correspondence to Svenja Happe, MD