Journal of Neurology

, Volume 250, Issue 1, pp 83–86

Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding

  • Svenja Happe
  • Walter Pirker
  • Gerhard Klösch
  • Cornelia Sauter
  • Josef Zeitlhofer
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-003-0957-8

Cite this article as:
Happe, S., Pirker, W., Klösch, G. et al. J Neurol (2003) 250: 83. doi:10.1007/s00415-003-0957-8

Abstract.

We used single photon emission computed tomography (SPECT) to study striatal [123I]β-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [123I]β-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients.

Key words [123I]β-CITParkinson's disease (PD)periodic leg movements during sleep (PLMS)polysomnographySPECT

Copyright information

© Steinkopff Verlag 2003

Authors and Affiliations

  • Svenja Happe
    • 1
  • Walter Pirker
    • 2
  • Gerhard Klösch
    • 2
  • Cornelia Sauter
    • 2
  • Josef Zeitlhofer
    • 2
  1. 1.Department of Clinical Neurophysiology, Robert-Koch-Strasse 40, 37075 Goettingen, Germany. shappe@gwdg.deDE
  2. 2.Department of Clinical Neurology, University of Vienna, AustriaAT