Journal of Neurology

, Volume 250, Issue 9, pp 1094–1098

Apolipoprotein E genotype does not influence the progression of multiple sclerosis

  • Giovanni SavettieriMD
  • Virginia AndreoliPhD
  • Simona BonavitaMD
  • Rita CittadellaPhD
  • Carlo CaltagironeMD
  • Maria Carolina FazioMD
  • Paolo GirlandaMD
  • Francesco Le PiraMD
  • Maria LiguoriMD
  • Giancarlo LogroscinoMD
  • Alessandra LugaresiMD
  • Ugo NocentiniMD
  • Arturo ReggioMD
  • Giuseppe SalemiMD
  • Paolo SerraPhD
  • Gioacchino TedeschiMD
  • Lucia TomaMD
  • Maria TrojanoMD
  • Paola ValentinoMD
  • Aldo QuattroneMD
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-003-0163-8

Cite this article as:
Savettieri, G., Andreoli, V., Bonavita, S. et al. J Neurol (2003) 250: 1094. doi:10.1007/s00415-003-0163-8

Abstract.

Objective:

To investigate the association between apolipoprotein E (APOE) polymorphisms and the progression of MS.

Methods:

We investigated 428 subjects affected by clinically defined MS, with a disease duration of at least three years. We collected data concerning the age at onset of MS, clinical type, disease duration and disability according to the expanded disability status scale (EDSS). We also calculated the progression index (PI) to evaluate disease progression. APOE genotyping and the –491 A/T polymorphism of the APOE promoter were determined.

Results:

No association was observed between the APOE ε4 allele and clinical characteristics of our study population. We also investigated the –491 A/T APOE promoter polymorphism in 236 MS subjects and did not find any association between the –491 A/T polymorphism and the selected clinical variables.

Conclusions:

In our population the APOE ε4 allele and the –491 A/T APOE promoter polymorphism are not associated with a more rapid course of MS.

Key words

multiple sclerosisAPOE polymorphismAPOE promoterMS progression

Copyright information

© Steinkopff Verlag 2003

Authors and Affiliations

  • Giovanni SavettieriMD
    • 1
  • Virginia AndreoliPhD
    • 2
  • Simona BonavitaMD
    • 3
  • Rita CittadellaPhD
    • 2
  • Carlo CaltagironeMD
    • 4
  • Maria Carolina FazioMD
    • 5
  • Paolo GirlandaMD
    • 5
  • Francesco Le PiraMD
    • 6
  • Maria LiguoriMD
    • 7
  • Giancarlo LogroscinoMD
    • 8
  • Alessandra LugaresiMD
    • 9
  • Ugo NocentiniMD
    • 4
  • Arturo ReggioMD
    • 6
  • Giuseppe SalemiMD
    • 1
  • Paolo SerraPhD
    • 2
  • Gioacchino TedeschiMD
    • 3
  • Lucia TomaMD
    • 9
  • Maria TrojanoMD
    • 7
  • Paola ValentinoMD
    • 10
  • Aldo QuattroneMD
    • 2
    • 10
    • 11
  1. 1.Institute of NeuropsychiatryUniversity of PalermoPalermoItaly
  2. 2.Institute of Neurological SciencesNational Research CouncilPiano Lago di Mangone (Cosenza)Italy
  3. 3.Dept. of Neurological Sciences2nd University of NaplesNaplesItaly
  4. 4.Cattedra di Neurologia and I.R.C.C.S., Fondazione "S. Lucia"University of Rome "Tor Vergata"RomeItaly
  5. 5.Dept. of Neurosciences, Psychiatry and AnaesthesiologyUniversity of MessinaMessinaItaly
  6. 6.Dept. of Neurological SciencesUniversity of CataniaCataniaItaly
  7. 7.Dept. of Neurological and Psychiatric SciencesUniversity of BariBariItaly
  8. 8.Dept. of NeurologyOspedale MiulliBariItaly
  9. 9.Dept. of Oncology & NeuroscienceUniversity of Chieti "Gabriele d’Annunzio"ChietiItaly
  10. 10.Institute of NeurologyUniversity Magna GraeciaCatanzaroItaly
  11. 11.Clinica NeurologicaPoliclinico Mater DominiCatanzaroItaly