Posterior reversible encephalopathy syndrome due to severe hypercalcemia
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- Kastrup, O., Maschke, M., Wanke, I. et al. J Neurol (2002) 249: 1563. doi:10.1007/s00415-002-0895-x
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Posterior reversible encephalopathy syndrome (PRES) is a leukoencephalopathy clinically characterized by headache, altered mental status, visual loss and seizures. Neuroimaging demonstrates symmetrical posterior cortical and subcortical lesions. The exact pathophysiology is unknown but there is a strong association with immunosuppressants and hypertension. We report two cases of PRES in normotensive patients with severe hypercalcemia as the only identifiable cause. Possible pathophysiological mechanisms are discussed.