Journal of Neurology

, Volume 249, Issue 11, pp 1563–1566

Posterior reversible encephalopathy syndrome due to severe hypercalcemia

  • O. Kastrup
  • M. Maschke
  • I. Wanke
  • H. C. Diener
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-002-0895-x

Cite this article as:
Kastrup, O., Maschke, M., Wanke, I. et al. J Neurol (2002) 249: 1563. doi:10.1007/s00415-002-0895-x

Abstract.

Posterior reversible encephalopathy syndrome (PRES) is a leukoencephalopathy clinically characterized by headache, altered mental status, visual loss and seizures. Neuroimaging demonstrates symmetrical posterior cortical and subcortical lesions. The exact pathophysiology is unknown but there is a strong association with immunosuppressants and hypertension. We report two cases of PRES in normotensive patients with severe hypercalcemia as the only identifiable cause. Possible pathophysiological mechanisms are discussed.

Key words posterior encephalopathy syndromehypercalcemiaMRI

Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • O. Kastrup
    • 1
  • M. Maschke
    • 1
  • I. Wanke
    • 1
  • H. C. Diener
    • 1
  1. 1.Neurologische Universitätsklinik, Hufelandstr. 55, 45122 Essen, Germany. oliver.kastrup@uni-essen.deDE